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    Maml1 mastermind-like transcriptional coactivator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303101, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Maml1provided by RGD
    Official Full Name
    mastermind-like transcriptional coactivator 1provided by RGD
    Primary source
    RGD:1308631
    See related
    EnsemblRapid:ENSRNOG00000003268 AllianceGenome:RGD:1308631
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable peptide antigen binding activity; protein kinase binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including atrioventricular node cell development; positive regulation of myotube differentiation; and positive regulation of transcription of Notch receptor target. Predicted to act upstream of or within Notch signaling pathway and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of MAML1-RBP-Jkappa- ICN1 complex. Predicted to be active in nucleoplasm. Orthologous to human MAML1 (mastermind like transcriptional coactivator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 44.8), Spleen (RPKM 39.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Maml1 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (35089715..35124100, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (34588639..34623024, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (35765196..35801375, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene sequestosome 1 Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B Neighboring gene uncharacterized LOC134480781 Neighboring gene leukotriene C4 synthase Neighboring gene uncharacterized LOC120095092 Neighboring gene calnexin Neighboring gene uncharacterized LOC134480780

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Notch pathway is activated in cell culture and mouse models of mutant SOD1-related familial amyotrophic lateral sclerosis, with suppression of its activation as an additional mechanism of neuroprotection for lithium and valproate. Wang SY, et al. Neuroscience, 2015 Aug 20. PMID 26067594
    2. Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways. Rentschler S, et al. J Clin Invest, 2011 Feb. PMID 21266778, Free PMC Article
    3. MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Wu L, et al. Nat Genet, 2000 Dec. PMID 11101851
    4. Cloning and functional characterization of the murine mastermind-like 1 (Maml1) gene. Wu L, et al. Gene, 2004 Mar 17. PMID 15019995
    5. The notch regulator MAML1 interacts with p53 and functions as a coactivator. Zhao Y, et al. J Biol Chem, 2007 Apr 20. PMID 17317671

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables peptide antigen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in atrioventricular node cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of myotube differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription of Notch receptor target IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription of Notch receptor target ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MAML1-RBP-Jkappa- ICN1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mastermind-like protein 1
    Names
    mastermind like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401556.1 → NP_001388485.1  mastermind-like protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D4A930
      Related
      ENSRNOP00000004361.6, ENSRNOT00000004361.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      35089715..35124100 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106997.1: Suppressed sequence

      Description
      NM_001106997.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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