Slc47a2 solute carrier family 47 member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc47a2provided by RGD
Official Full Name: solute carrier family 47 member 2provided by RGD
Primary source: RGD:1562382
See related: EnsemblRapid:ENSRNOG00000038055 AllianceGenome:RGD:1562382
Gene type: protein coding
RefSeq status: INFERRED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562382
Summary: Predicted to enable organic cation transmembrane transporter activity and polyspecific organic cation:proton antiporter activity. Predicted to be involved in organic cation transport. Predicted to be located in plasma membrane. Predicted to be active in membrane. Orthologous to human SLC47A2 (solute carrier family 47 member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 36.0), Kidney (RPKM 4.6) and 1 other tissue See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 10q22

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (46490262..46532954, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (45990806..46033937, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (47587909..47631373, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

RH134186 (e-PCR)
- UniSTS:217468

BI288337 (e-PCR)
- UniSTS:246155

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables antiporter activity	ISO Inferred from Sequence Orthology more info
enables organic cation transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables polyspecific organic cation:proton antiporter activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables xenobiotic transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in organic cation transport	ISO Inferred from Sequence Orthology more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: multidrug and toxin extrusion protein 2

Names: solute carrier family 47 (multidrug and toxin extrusion), member 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191920.1 → NP_001178849.1 multidrug and toxin extrusion protein 2

Status: INFERRED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

D4A4W2

Related

ENSRNOP00000103370.1, ENSRNOT00000157249.1

Conserved Domains (2) summary

COG0534
Location:52 → 478

NorM; Na+-driven multidrug efflux pump [Defense mechanisms]

cd13132
Location:51 → 476

MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

46490262..46532954 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086568.2 → XP_038942496.1 multidrug and toxin extrusion protein 2 isoform X1

Conserved Domains (1) summary

cd13132
Location:51 → 412

MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family
XM_039086569.2 → XP_038942497.1 multidrug and toxin extrusion protein 2 isoform X2

Conserved Domains (1) summary

cd13132
Location:51 → 445

MATE_eukaryotic; Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family