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    Septin14 septin 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689118, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Septin14provided by RGD
    Official Full Name
    septin 14provided by RGD
    Primary source
    RGD:1596186
    See related
    EnsemblRapid:ENSRNOG00000038495 AllianceGenome:RGD:1596186
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sept14
    Summary
    Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in several processes, including neuron migration; protein localization to perinuclear region of cytoplasm; and spermatid development. Predicted to be located in several cellular components, including acrosomal vesicle; perikaryon; and perinuclear region of cytoplasm. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human SEPTIN14 (septin 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 147.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Septin14 in Genome Data Viewer
    Location:
    12q13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (32610600..32641391)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (26975283..27005588)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (30600162..30623173)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene nipsnap homolog 2 Neighboring gene small nucleolar RNA SNORA76 Neighboring gene mitochondrial ribosomal protein S17 Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene zinc finger protein 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SEPT14 Is Associated with a Reduced Risk for Parkinson's Disease and Expressed in Human Brain. Rozenkrantz L, et al. J Mol Neurosci, 2016 Jul. PMID 27115672
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    septin-14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368669.2 → NP_001355598.1  septin-14

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A1W2Q660
      Conserved Domains (1) summary
      cd01850
      Location:48 → 314
      CDC_Septin; CDC/Septin GTPase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      32610600..32641391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089767.2 → XP_038945695.1  septin-14 isoform X1

      Related
      ENSRNOP00000076145.3, ENSRNOT00000093601.3
      Conserved Domains (1) summary
      cd01850
      Location:48 → 314
      CDC_Septin; CDC/Septin GTPase family

    2. XM_039089768.2 → XP_038945696.1  septin-14 isoform X2

      Conserved Domains (1) summary
      cd01850
      Location:48 → 310
      CDC_Septin; CDC/Septin GTPase family

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001137670.1: Suppressed sequence

      Description
      NM_001137670.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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