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    Piwil1 piwi-like RNA-mediated gene silencing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363912, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Piwil1provided by RGD
    Official Full Name
    piwi-like RNA-mediated gene silencing 1provided by RGD
    Primary source
    RGD:1306980
    See related
    EnsemblRapid:ENSRNOG00000000934 AllianceGenome:RGD:1306980
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including RNA binding activity; mRNA cap binding complex binding activity; and protein kinase binding activity. Predicted to be involved in piRNA-mediated retrotransposon silencing by heterochromatin formation; primary piRNA processing; and sperm DNA condensation. Predicted to be located in chromatoid body and dense body. Predicted to be active in P granule and nucleus. Orthologous to human PIWIL1 (piwi like RNA-mediated gene silencing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 72.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Piwil1 in Genome Data Viewer
    Location:
    12q13
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (33585747..33606715, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (27949743..27970645, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (31608641..31629961, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene translation machinery-associated protein 7-like Neighboring gene RIMS binding protein 2 Neighboring gene uncharacterized LOC108352441 Neighboring gene uncharacterized LOC134481180 Neighboring gene frizzled class receptor 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Timed regulation of P-element-induced wimpy testis-interacting RNA expression during rat liver regeneration. Rizzo F, et al. Hepatology, 2014 Sep. PMID 24930433
    2. Novel function of PIWIL1 in neuronal polarization and migration via regulation of microtubule-associated proteins. Zhao PP, et al. Mol Brain, 2015 Jun 24. PMID 26104391, Free PMC Article
    3. A novel class of small RNAs in mouse spermatogenic cells. Grivna ST, et al. Genes Dev, 2006 Jul 1. PMID 16766680, Free PMC Article
    4. piRNA-triggered MIWI ubiquitination and removal by APC/C in late spermatogenesis. Zhao S, et al. Dev Cell, 2013 Jan 14. PMID 23328397
    5. Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing. Reuter M, et al. Nature, 2011 Nov 27. PMID 22121019

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PIWIL1 regulates neuronal polarization and radial migration partly via modulating the expression of microtubule-associated proteins.
      Title: Novel function of PIWIL1 in neuronal polarization and migration via regulation of microtubule-associated proteins.
    2. RNAs encoding PIWIL2/HILI, PIWIL4/HIWI2 and other components of the piRNA biogenesis pathways are identified in the normal rat liver during regenerative proliferation.
      Title: Timed regulation of P-element-induced wimpy testis-interacting RNA expression during rat liver regeneration.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA cap binding complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables piRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables piRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in piRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piRNA-mediated gene silencing by mRNA destabilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in piRNA-mediated gene silencing by mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in primary piRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA-mediated gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm DNA condensation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transposable element silencing by piRNA-mediated heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatoid body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dense body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    piwi-like protein 1
    Names
    piwi like homolog 1
    piwi-like 1
    NP_001102323.1
    XP_017453899.1
    XP_038945560.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108853.3 → NP_001102323.1  piwi-like protein 1

      See identical proteins and their annotated locations for NP_001102323.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I6A0Y7, A6J0T4, D3ZTP9
      Conserved Domains (3) summary
      smart00949
      Location:278 → 416
      PAZ; This domain is named PAZ after the proteins Piwi Argonaut and Zwille
      cd04658
      Location:402 → 845
      Piwi_piwi-like_Euk; PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of related ...
      pfam05831
      Location:16 → 107
      GAGE; GAGE protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      33585747..33606715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598410.3 → XP_017453899.1  piwi-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A0Y7
      Related
      ENSRNOP00000001238.5, ENSRNOT00000001238.7
      Conserved Domains (3) summary
      smart00949
      Location:279 → 417
      PAZ; This domain is named PAZ after the proteins Piwi Argonaut and Zwille
      cd04658
      Location:403 → 846
      Piwi_piwi-like_Euk; PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of related ...
      pfam05831
      Location:16 → 108
      GAGE; GAGE protein

    2. XM_039089632.2 → XP_038945560.1  piwi-like protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A0Y7
      Conserved Domains (3) summary
      smart00949
      Location:279 → 417
      PAZ; This domain is named PAZ after the proteins Piwi Argonaut and Zwille
      cd04658
      Location:403 → 846
      Piwi_piwi-like_Euk; PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of related ...
      pfam05831
      Location:16 → 108
      GAGE; GAGE protein
    Nucleotide Protein Strain
    Heading Accession and Version

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