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    Slc26a9 solute carrier family 26 member 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304784, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc26a9provided by RGD
    Official Full Name
    solute carrier family 26 member 9provided by RGD
    Primary source
    RGD:1310441
    See related
    EnsemblRapid:ENSRNOG00000029514 AllianceGenome:RGD:1310441
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including ATPase binding activity; inorganic anion transmembrane transporter activity; and oxalate transmembrane transporter activity. Predicted to be involved in chloride transmembrane transport; positive regulation of gene expression; and sulfate transmembrane transport. Predicted to act upstream of or within bicarbonate transport; chloride transport; and regulation of pH. Predicted to be located in apical plasma membrane and cell surface. Predicted to be active in bounding membrane of organelle; endoplasmic reticulum membrane; and plasma membrane. Orthologous to human SLC26A9 (solute carrier family 26 member 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 40.1), Kidney (RPKM 10.8) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc26a9 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (45730022..45757662)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (43177806..43205450)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (48512415..48539467)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene Rab7b, member RAS oncogene family Neighboring gene uncharacterized LOC134481493 Neighboring gene uncharacterized LOC103691878 Neighboring gene peptidase M20 domain containing 1 Neighboring gene solute carrier family 41 member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of nonsynonymous single nucleotide polymorphisms in human SLC26A9. Chen AP, et al. Hum Mutat, 2012 Aug. PMID 22544634, Free PMC Article
    2. Characterization of SLC26A9, facilitation of Cl(-) transport by bicarbonate. Loriol C, et al. Cell Physiol Biochem, 2008. PMID 18769029
    3. Identification of SLC26A transporters involved in the Cl⁻/HCO₃⁻ exchange in proximal tubular cells from WKY and SHR. Simão S, et al. Life Sci, 2013 Oct 6. PMID 23933130
    4. SLC26A9 is a constitutively active, CFTR-regulated anion conductance in human bronchial epithelia. Bertrand CA, et al. J Gen Physiol, 2009 Apr. PMID 19289574, Free PMC Article
    5. SLC26A9 stimulates CFTR expression and function in human bronchial cell lines. Avella M, et al. J Cell Physiol, 2011 Jan. PMID 20658517

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of slc26a4, slc26a6 and slc26a9 is increased in proximal tubule epithelial cells from spontaneously hypertensive rats compared with WKY control rats.
      Title: Identification of SLC26A transporters involved in the Cl⁻/HCO₃⁻ exchange in proximal tubular cells from WKY and SHR.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables bicarbonate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bicarbonate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chloride transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride:bicarbonate antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxalate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables solute:inorganic anion antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within bicarbonate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chloride transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chloride transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic anion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oxalate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of pH ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 26 member 9
    Names
    solute carrier family 26 (anion exchanger), member 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107172.1 → NP_001100642.1  solute carrier family 26 member 9

      See identical proteins and their annotated locations for NP_001100642.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473958
      UniProtKB/TrEMBL
      A6IC30, D3ZV32
      Related
      ENSRNOP00000009742.4, ENSRNOT00000009742.6
      Conserved Domains (1) summary
      TIGR00815
      Location:57 → 733
      sulP; high affinity sulphate transporter 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      45730022..45757662
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090696.1 → XP_038946624.1  solute carrier family 26 member 9 isoform X3

      Conserved Domains (1) summary
      pfam00916
      Location:74 → 468
      Sulfate_transp; Sulfate permease family

    2. XM_017598789.3 → XP_017454278.2  solute carrier family 26 member 9 isoform X1

      UniProtKB/TrEMBL
      A6IC30, D3ZV32
      Conserved Domains (1) summary
      TIGR00815
      Location:57 → 733
      sulP; high affinity sulphate transporter 1

    3. XM_039090695.1 → XP_038946623.1  solute carrier family 26 member 9 isoform X2

      Conserved Domains (1) summary
      TIGR00815
      Location:8 → 569
      sulP; high affinity sulphate transporter 1
    Nucleotide Protein Strain
    Heading Accession and Version

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