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    Acox3 acyl-CoA oxidase 3, pristanoyl [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83522, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acox3provided by RGD
    Official Full Name
    acyl-CoA oxidase 3, pristanoylprovided by RGD
    Primary source
    RGD:69245
    See related
    EnsemblRapid:ENSRNOG00000008474 AllianceGenome:RGD:69245
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables fatty acid binding activity; flavin adenine dinucleotide binding activity; and pristanoyl-CoA oxidase activity. Involved in fatty acid beta-oxidation using acyl-CoA oxidase. Located in peroxisome. Orthologous to human ACOX3 (acyl-CoA oxidase 3, pristanoyl). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 370.5), Kidney (RPKM 90.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Acox3 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (79358604..79405160, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (75133986..75176767, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (80313202..80358115, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene SH3 domain and tetratricopeptide repeats 1 Neighboring gene HtrA serine peptidase 3 Neighboring gene tRNA methyltransferase 44 Neighboring gene carboxypeptidase Z Neighboring gene uncharacterized LOC120096640

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rat pristanoyl-CoA oxidase. cDNA cloning and recognition of its C-terminal (SQL) by the peroxisomal-targeting signal 1 receptor. Vanhooren JC, et al. Eur J Biochem, 1996 Jul 15. PMID 8706733
    2. Large-scale purification and further characterization of rat pristanoyl-CoA oxidase. Van Veldhoven PP, et al. Eur J Biochem, 1994 Jun 15. PMID 8026493
    3. Peroxisomal beta-oxidation of 2-methyl-branched acyl-CoA esters: stereospecific recognition of the 2S-methyl compounds by trihydroxycoprostanoyl-CoA oxidase and pristanoyl-CoA oxidase. Van Veldhoven PP, et al. FEBS Lett, 1996 Jun 10. PMID 8654595
    4. Mammalian peroxisomal acyl-CoA oxidases. III. Molecular characterization of human branched chain fatty acyl-CoA oxidase. Baumgart E, et al. Ann N Y Acad Sci, 1996 Dec 27. PMID 8993592
    5. Substrate specificities of rat liver peroxisomal acyl-CoA oxidases: palmitoyl-CoA oxidase (inducible acyl-CoA oxidase), pristanoyl-CoA oxidase (non-inducible acyl-CoA oxidase), and trihydroxycoprostanoyl-CoA oxidase. Van Veldhoven PP, et al. J Biol Chem, 1992 Oct 5. PMID 1400324

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyl-CoA oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fatty acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables flavin adenine dinucleotide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pristanoyl-CoA oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pristanoyl-CoA oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pristanoyl-CoA oxidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal acyl-coenzyme A oxidase 3
    Names
    BRCACox
    acyl-Coenzyme A oxidase 3, pristanoyl
    branched-chain acyl-CoA oxidase
    pristanoyl-CoA oxidase
    NP_445791.2
    XP_017454881.1
    XP_038948424.1
    XP_063129745.1
    XP_063129746.1
    XP_063129747.1
    XP_063129748.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053339.2 → NP_445791.2  peroxisomal acyl-coenzyme A oxidase 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A6IJZ3, F1M9A7
      Related
      ENSRNOP00000092103.2, ENSRNOT00000110399.2
      Conserved Domains (1) summary
      cd01150
      Location:19 → 672
      AXO; Peroxisomal acyl-CoA oxidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      79358604..79405160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273675.1 → XP_063129745.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AGJ0, A0A8I6G857

    2. XM_017599392.3 → XP_017454881.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X2

      UniProtKB/TrEMBL
      A6IJZ3, F1M9A7
      Conserved Domains (1) summary
      cd01150
      Location:19 → 672
      AXO; Peroxisomal acyl-CoA oxidase

    3. XM_039092496.2 → XP_038948424.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X2

      UniProtKB/TrEMBL
      A6IJZ3, F1M9A7
      Conserved Domains (1) summary
      cd01150
      Location:19 → 672
      AXO; Peroxisomal acyl-CoA oxidase

    4. XM_063273676.1 → XP_063129746.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X3

    5. XM_063273677.1 → XP_063129747.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X4

    6. XM_063273678.1 → XP_063129748.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63448.1 GenPept UniProtKB/Swiss-Prot:Q63448

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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