Dok7 docking protein 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dok7provided by RGD
Official Full Name: docking protein 7provided by RGD
Primary source: RGD:1566416
See related: EnsemblRapid:ENSRNOG00000022419 AllianceGenome:RGD:1566416
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1566416
Summary: Predicted to enable phosphatidylinositol binding activity; protein kinase binding activity; and signaling adaptor activity. Predicted to be involved in several processes, including positive regulation of Rac protein signal transduction; positive regulation of protein tyrosine kinase activity; and positive regulation of skeletal muscle acetylcholine-gated channel clustering. Predicted to act upstream of or within positive regulation of protein phosphorylation and receptor clustering. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be active in neuromuscular junction and postsynaptic membrane. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 10 and fetal akinesia deformation sequence syndrome 3. Orthologous to human DOK7 (docking protein 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 44.8), Heart (RPKM 42.2) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (79890051..79924081, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (75665444..75699413, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (80925409..80963454, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A reduced expression of Dok-7 may play a role in the susceptibility to passive transfer Myasthenia gravis (MG), by rendering acetylcholine receptor (AChR) clusters less resistant to the autoantibody attack.
Title: Silencing of Dok-7 in Adult Rat Muscle Increases Susceptibility to Passive Transfer Myasthenia Gravis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in enzyme-linked receptor protein signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular junction development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuromuscular junction development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering	ISO Inferred from Sequence Orthology more info
acts_upstream_of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within receptor clustering	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein Dok-7

Names: downstream of tyrosine kinase 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001130062.2 → NP_001123534.2 protein Dok-7 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014
NM_001414957.1 → NP_001401886.1 protein Dok-7 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0A8I6GLL7

Related

ENSRNOP00000096459.2, ENSRNOT00000118992.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

79890051..79924081 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017599206.3 → XP_017454695.1 protein Dok-7 isoform X3
XM_039091973.2 → XP_038947901.1 protein Dok-7 isoform X4

Conserved Domains (3) summary

PHA03307
Location:291 → 449

PHA03307; transcriptional regulator ICP4; Provisional

cd13165
Location:26 → 123

PTB_DOK7; Downstream of tyrosine kinase 7 phosphotyrosine-binding domain (PTBi)

cl17171
Location:6 → 25

PH-like; Pleckstrin homology-like domain
XM_039091972.2 → XP_038947900.1 protein Dok-7 isoform X2

UniProtKB/TrEMBL

A6IK09, D3ZDW9

Conserved Domains (3) summary

PHA03307
Location:339 → 497

PHA03307; transcriptional regulator ICP4; Provisional

cd13165
Location:71 → 171

PTB_DOK7; Downstream of tyrosine kinase 7 phosphotyrosine-binding domain (PTBi)

cl17171
Location:1 → 70

PH-like; Pleckstrin homology-like domain
XM_017599205.3 → XP_017454694.1 protein Dok-7 isoform X1

Related

ENSRNOP00000036262.5, ENSRNOT00000035385.6
XM_063273153.1 → XP_063129223.1 protein Dok-7 isoform X5

UniProtKB/TrEMBL

A0A8I5ZVQ6

Related

ENSRNOP00000083030.1, ENSRNOT00000098833.2