Ipo4 importin 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ipo4provided by RGD
Official Full Name: importin 4provided by RGD
Primary source: RGD:1305206
See related: EnsemblRapid:ENSRNOG00000019553 AllianceGenome:RGD:1305206
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to be located in chromatin. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human IPO4 (importin 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 126.5), Adrenal (RPKM 79.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p13

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (33087321..33097241, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (29117365..29127382, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (34304425..34314552, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH125867 (e-PCR)
- UniSTS:162603

RH134464 (e-PCR)
- UniSTS:217744

RH129403 (e-PCR)
- UniSTS:212710

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear import signal receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear localization sequence binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: importin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106038.1 → NP_001099508.1 importin-4

See identical proteins and their annotated locations for NP_001099508.1

Status: PROVISIONAL

Source sequence(s)

CH474049

UniProtKB/TrEMBL

A0A8I6ABI2, A6KH24, D4A2D7

Related

ENSRNOP00000026552.5, ENSRNOT00000026552.8

Conserved Domains (4) summary

smart00913
Location:24 → 90

IBN_N; Importin-beta N-terminal domain

COG5215
Location:1 → 620

KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]

pfam02985
Location:395 → 425

HEAT; HEAT repeat

sd00044
Location:353 → 381

HEAT; HEAT repeat [structural motif]