Dzip1 DAZ interacting zinc finger protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dzip1provided by RGD
Official Full Name: DAZ interacting zinc finger protein 1provided by RGD
Primary source: RGD:1307701
See related: EnsemblRapid:ENSRNOG00000010311 AllianceGenome:RGD:1307701
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable BBSome binding activity and molecular adaptor activity. Predicted to be involved in several processes, including cilium organization; positive regulation of protein localization to cilium; and protein-containing complex localization to centriolar satellite. Predicted to act upstream of or within several processes, including maintenance of protein location; positive regulation of cilium assembly; and protein localization to cilium. Predicted to be located in ciliary base; microtubule organizing center; and nuclear speck. Predicted to be part of ciliary transition fiber. Predicted to be active in ciliary basal body and cytoplasm. Human ortholog(s) of this gene implicated in mitral valve prolapse and spermatogenic failure 47. Orthologous to human DZIP1 (DAZ interacting zinc finger protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 322.0), Brain (RPKM 176.8) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q24

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (102363392..102417085, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (95956329..96009994, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (104117551..104168574, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dzip1S mRNA was confined to the spermatogenic lineage, specifically premeiotic spermatogonia
Title: Characterization of structure and expression of the Dzip1 gene in the rat and mouse.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables BBSome binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ciliary basal body organization	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cilium organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytoplasmic sequestering of protein	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in germ cell development	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within maintenance of protein location in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to cilium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to cilium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to organelle	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex localization to centriolar satellite	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in sperm flagellum assembly	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in ciliary base	ISO Inferred from Sequence Orthology more info
part_of ciliary transition fiber	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cilium assembly protein DZIP1

Names: DAZ interacting protein 1; zinc finger protein DZIP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427239.1 → NP_001414168.1 cilium assembly protein DZIP1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A0A1W2Q6C7, A0A8I5ZVC1

Related

ENSRNOP00000082462.1, ENSRNOT00000106262.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

102363392..102417085 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063274506.1 → XP_063130576.1 cilium assembly protein DZIP1 isoform X7

UniProtKB/TrEMBL

A0A8I6A380, F1MA25
XM_063274498.1 → XP_063130568.1 cilium assembly protein DZIP1 isoform X1

UniProtKB/TrEMBL

A0A1W2Q6C7
XM_063274504.1 → XP_063130574.1 cilium assembly protein DZIP1 isoform X7

UniProtKB/TrEMBL

A0A8I6A380, F1MA25
XM_063274496.1 → XP_063130566.1 cilium assembly protein DZIP1 isoform X1

UniProtKB/TrEMBL

A0A1W2Q6C7
XM_063274505.1 → XP_063130575.1 cilium assembly protein DZIP1 isoform X7

UniProtKB/TrEMBL

A0A8I6A380, F1MA25
XM_063274499.1 → XP_063130569.1 cilium assembly protein DZIP1 isoform X1

UniProtKB/TrEMBL

A0A1W2Q6C7
XM_006252466.4 → XP_006252528.1 cilium assembly protein DZIP1 isoform X7

See identical proteins and their annotated locations for XP_006252528.1

UniProtKB/TrEMBL

A0A8I6A380, F1MA25

Conserved Domains (2) summary

sd00017
Location:142 → 163

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13815
Location:2 → 120

Dzip-like_N; Iguana/Dzip1-like DAZ-interacting protein N-terminal
XM_039093981.2 → XP_038949909.1 cilium assembly protein DZIP1 isoform X4

UniProtKB/TrEMBL

A0A1W2Q6C7, A0A8I5ZVC1

Conserved Domains (3) summary

COG1196
Location:114 → 439

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

sd00018
Location:183 → 207

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13815
Location:43 → 163

Dzip-like_N; Iguana/Dzip1-like DAZ-interacting protein N-terminal
XM_063274497.1 → XP_063130567.1 cilium assembly protein DZIP1 isoform X1

UniProtKB/TrEMBL

A0A1W2Q6C7
XM_063274507.1 → XP_063130577.1 cilium assembly protein DZIP1 isoform X8

UniProtKB/TrEMBL

F1MA25
XM_063274509.1 → XP_063130579.1 cilium assembly protein DZIP1 isoform X9

UniProtKB/TrEMBL

F1MA25
XM_063274502.1 → XP_063130572.1 cilium assembly protein DZIP1 isoform X5

UniProtKB/TrEMBL

A0A1W2Q6C7
XM_063274503.1 → XP_063130573.1 cilium assembly protein DZIP1 isoform X6

UniProtKB/TrEMBL

A0A1W2Q6C7
XM_063274500.1 → XP_063130570.1 cilium assembly protein DZIP1 isoform X2

UniProtKB/TrEMBL

A0A1W2Q6C7
XM_063274501.1 → XP_063130571.1 cilium assembly protein DZIP1 isoform X3

UniProtKB/TrEMBL

A0A1W2Q6C7
XM_039093987.2 → XP_038949915.1 cilium assembly protein DZIP1 isoform X10