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    Anxa11 annexin A11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290527, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Anxa11provided by RGD
    Official Full Name
    annexin A11provided by RGD
    Primary source
    RGD:1309911
    See related
    EnsemblRapid:ENSRNOG00000010984 AllianceGenome:RGD:1309911
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including S100 protein binding activity; calcium-dependent protein binding activity; and phospholipid binding activity. Predicted to be involved in cytokinetic process; phagocytosis; and response to calcium ion. Predicted to be located in several cellular components, including cytoplasmic vesicle; midbody; and nucleus. Predicted to be active in several cellular components, including nucleus; plasma membrane; and vesicle membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 23 and inclusion body myopathy and brain white matter abnormalities. Orthologous to human ANXA11 (annexin A11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 444.2), Kidney (RPKM 350.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Anxa11 in Genome Data Viewer
    Location:
    16p16
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (1419627..1464590)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (1412373..1457814)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (3867193..3912043, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated like 1 Neighboring gene dCTP pyrophosphatase 1, pseudogene 2 Neighboring gene placenta associated 9 Neighboring gene uncharacterized LOC134482312

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment. Lillebostad PAG, et al. Biomolecules, 2020 Apr 24. PMID 32344647, Free PMC Article
    2. The 56K autoantigen is identical to human annexin XI. Misaki Y, et al. J Biol Chem, 1994 Feb 11. PMID 7508441
    3. Translocation of annexin XI to neutrophil subcellular organelles. Sjölin C, et al. Biochim Biophys Acta, 1997 May 22. PMID 9188810
    4. Structural and functional characterization of recombinant mouse annexin A11: influence of calcium binding. Lecona E, et al. Biochem J, 2003 Jul 15. PMID 12689336, Free PMC Article
    5. Annexin 11 is required for midbody formation and completion of the terminal phase of cytokinesis. Tomas A, et al. J Cell Biol, 2004 Jun 21. PMID 15197175, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment.
      Title: Structure of the ALS Mutation Target Annexin A11 Reveals a Stabilising N-Terminal Segment.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables S100 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylethanolamine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cytokinetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytokinetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phagocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in azurophil granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in specific granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    annexin A11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011918.1 → NP_001011918.1  annexin A11

      See identical proteins and their annotated locations for NP_001011918.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083812
      UniProtKB/TrEMBL
      A6KMI0, Q5XI77
      Related
      ENSRNOP00000104280.1, ENSRNOT00000156046.1
      Conserved Domains (1) summary
      pfam00191
      Location:202 → 267
      Annexin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      1419627..1464590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094245.2 → XP_038950173.1  annexin A11 isoform X2

      Conserved Domains (1) summary
      pfam00191
      Location:202 → 267
      Annexin

    2. XM_017600010.3 → XP_017455499.1  annexin A11 isoform X1

      UniProtKB/TrEMBL
      A6KMI0, Q5XI77
      Conserved Domains (1) summary
      pfam00191
      Location:202 → 267
      Annexin
    Nucleotide Protein Strain
    Heading Accession and Version

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