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    Galntl6 polypeptide N-acetylgalactosaminyltransferase-like 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361142, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Galntl6provided by RGD
    Official Full Name
    polypeptide N-acetylgalactosaminyltransferase-like 6provided by RGD
    Primary source
    RGD:1564773
    See related
    EnsemblRapid:ENSRNOG00000067282 AllianceGenome:RGD:1564773
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Galnt17; RGD1564773
    Summary
    Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation via threonine. Predicted to be located in Golgi membrane. Orthologous to human GALNTL6 (polypeptide N-acetylgalactosaminyltransferase like 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 38.8) and Heart (RPKM 1.4) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Galntl6 in Genome Data Viewer
    Location:
    16p12-p11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (36203674..37454709)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (31192880..32443979)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (34551052..35803840)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120097434 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene myeloid-associated differentiation marker-like Neighboring gene U6atac minor spliceosomal RNA Neighboring gene ribosomal protein S27a, pseudogene 14 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC134482370 Neighboring gene uncharacterized LOC120097422 Neighboring gene uncharacterized LOC120097421 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CircRNA Galntl6 sponges miR-335 to ameliorate stress-induced hypertension through upregulating Lig3 in rostral ventrolateral medulla. Zhang S, et al. Redox Biol, 2023 Aug. PMID 37315345, Free PMC Article
    2. UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family tree. Raman J, et al. Glycobiology, 2012 Jun. PMID 22186971, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircRNA Galntl6 sponges miR-335 to ameliorate stress-induced hypertension through upregulating Lig3 in rostral ventrolateral medulla.
      Title: CircRNA Galntl6 sponges miR-335 to ameliorate stress-induced hypertension through upregulating Lig3 in rostral ventrolateral medulla.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation via threonine ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    polypeptide N-acetylgalactosaminyltransferase-like 6
    Names
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6
    polypeptide N-acetylgalactosaminyltransferase 17
    NP_001129228.1
    XP_017455671.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135756.1 → NP_001129228.1  polypeptide N-acetylgalactosaminyltransferase-like 6

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I5ZYW6
      Conserved Domains (4) summary
      cd02510
      Location:143 → 438
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      cd00161
      Location:456 → 584
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:454 → 582
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
      pfam13641
      Location:140 → 365
      Glyco_tranf_2_3; Glycosyltransferase like family 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      36203674..37454709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600182.3 → XP_017455671.1  polypeptide N-acetylgalactosaminyltransferase-like 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYW6
      Related
      ENSRNOP00000083243.1, ENSRNOT00000109059.2
      Conserved Domains (4) summary
      cd02510
      Location:143 → 438
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      cd00161
      Location:456 → 584
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:454 → 582
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
      pfam13641
      Location:140 → 365
      Glyco_tranf_2_3; Glycosyltransferase like family 2
    Nucleotide Protein Strain
    Heading Accession and Version

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