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    Timm23 translocase of inner mitochondrial membrane 23 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54312, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Timm23provided by RGD
    Official Full Name
    translocase of inner mitochondrial membrane 23provided by RGD
    Primary source
    RGD:3863
    See related
    EnsemblRapid:ENSRNOG00000019811 AllianceGenome:RGD:3863
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables enzyme binding activity. Involved in intracellular protein transport; positive regulation of protein processing; and response to 3,3',5-triiodo-L-thyronine. Located in mitochondrial inner membrane. Biomarker of muscular atrophy. Orthologous to several human genes including TIMM23 (translocase of inner mitochondrial membrane 23). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 1179.2), Heart (RPKM 773.6) and 9 other tissues See more
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    Genomic context

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    See Timm23 in Genome Data Viewer
    Location:
    16p16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (7416590..7442681, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (7410308..7436392, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (8324038..8350067, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482455 Neighboring gene microseminoprotein, beta Neighboring gene poly (ADP-ribose) glycohydrolase like 1 Neighboring gene nuclear receptor coactivator 4 Neighboring gene small nucleolar RNA SNORA74 Neighboring gene poly (ADP-ribose) glycohydrolase Neighboring gene uncharacterized LOC134482454 Neighboring gene uncharacterized LOC102550503

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Effect of denervation-induced muscle disuse on mitochondrial protein import. Singh K, et al. Am J Physiol Cell Physiol, 2011 Jan. PMID 20943961
    2. Functional consequences of thyroid hormone-induced changes in the mitochondrial protein import pathway. Colavecchia M, et al. Am J Physiol Endocrinol Metab, 2003 Jan. PMID 12388124
    3. Characterization of the initial steps of precursor import into rat liver mitoplasts. Ishihara N, et al. J Biochem, 1998 Oct. PMID 9756630
    4. Identification of the protein import components of the rat mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44. Ishihara N, et al. J Biochem, 1998 Apr. PMID 9538267
    5. Role of Bax and Bak in mitochondrial morphogenesis. Karbowski M, et al. Nature, 2006 Oct 12. PMID 17035996

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93478

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to 3,3',5-triiodo-L-thyronine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in type 2 mitophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in type 2 mitophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of TIM23 mitochondrial import inner membrane translocase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TIM23 mitochondrial import inner membrane translocase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of TIM23 mitochondrial import inner membrane translocase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in migrasome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial import inner membrane translocase subunit Tim23
    Names
    translocase of inner mitochondrial membrane 23 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019352.2 → NP_062225.1  mitochondrial import inner membrane translocase subunit Tim23

      See identical proteins and their annotated locations for NP_062225.1

      Status: PROVISIONAL

      Source sequence(s)
      AB006451
      UniProtKB/Swiss-Prot
      O35093
      UniProtKB/TrEMBL
      A0A8I6A2G5
      Related
      ENSRNOP00000103919.1, ENSRNOT00000124649.1
      Conserved Domains (1) summary
      TIGR00983
      Location:46 → 191
      3a0801s02tim23; mitochondrial import inner membrane translocase subunit tim23

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      7416590..7442681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275668.1 → XP_063131738.1  mitochondrial import inner membrane translocase subunit Tim23 isoform X1

      UniProtKB/TrEMBL
      A6KFW6

    2. XM_039094791.2 → XP_038950719.1  mitochondrial import inner membrane translocase subunit Tim23 isoform X2

      UniProtKB/TrEMBL
      A6KFW6
      Conserved Domains (1) summary
      cl02381
      Location:46 → 114
      Tim17; Tim17/Tim22/Tim23/Pmp24 family

    RNA

    1. XR_010058311.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35093.1 GenPept UniProtKB/Swiss-Prot:O35093

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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