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    Wdr37 WD repeat domain 37 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307075, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wdr37provided by RGD
    Official Full Name
    WD repeat domain 37provided by RGD
    Primary source
    RGD:1306189
    See related
    EnsemblRapid:ENSRNOG00000016834 AllianceGenome:RGD:1306189
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in lymphocyte homeostasis. Predicted to act upstream of or within corpus callosum development. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in neurooculocardiogenitourinary syndrome. Orthologous to human WDR37 (WD repeat domain 37). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 167.7), Heart (RPKM 82.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wdr37 in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (66547425..66613841)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (61637258..61703677)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (57983937..58051011)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100911936 Neighboring gene uncharacterized LOC134482733 Neighboring gene uncharacterized LOC134482867 Neighboring gene isopentenyl-diphosphate delta isomerase 1 Neighboring gene adenosine deaminase RNA specific B2 Neighboring gene uncharacterized LOC134482734 Neighboring gene uncharacterized LOC102552293

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. De Novo Missense Variants in WDR37 Cause a Severe Multisystemic Syndrome. Reis LM, et al. Am J Hum Genet, 2019 Aug 1. PMID 31327510, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within corpus callosum development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lymphocyte homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 37

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107362.2 → NP_001100832.1  WD repeat-containing protein 37 isoform 2

      See identical proteins and their annotated locations for NP_001100832.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6GF74, A6KRN7, D3ZQ02
      Related
      ENSRNOP00000022688.5, ENSRNOT00000022688.7
      Conserved Domains (3) summary
      COG2319
      Location:73 → 441
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:116 → 439
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:239 → 275
      7WD40; WD40 repeat [structural motif]

    2. NM_001399297.1 → NP_001386226.1  WD repeat-containing protein 37 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6GF74
      Related
      ENSRNOP00000101152.1, ENSRNOT00000123865.1
      Conserved Domains (2) summary
      cd00200
      Location:128 → 438
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:203 → 281
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      66547425..66613841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095771.2 → XP_038951699.1  WD repeat-containing protein 37 isoform X3

      Conserved Domains (2) summary
      sd00039
      Location:159 → 196
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:147 → 323
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_039095769.2 → XP_038951697.1  WD repeat-containing protein 37 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GF74
      Related
      ENSRNOP00000086670.1, ENSRNOT00000104845.2
      Conserved Domains (2) summary
      cd00200
      Location:128 → 438
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:203 → 281
      7WD40; WD40 repeat [structural motif]

    3. XM_039095770.2 → XP_038951698.1  WD repeat-containing protein 37 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AE33, A0A8I6GF74
      Related
      ENSRNOP00000107974.1, ENSRNOT00000136396.1
      Conserved Domains (2) summary
      cd00200
      Location:111 → 449
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:166 → 244
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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