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    Epc1 enhancer of polycomb homolog 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100362678, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Epc1provided by RGD
    Official Full Name
    enhancer of polycomb homolog 1provided by RGD
    Primary source
    RGD:2324280
    See related
    EnsemblRapid:ENSRNOG00000014834 AllianceGenome:RGD:2324280
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin-protein adaptor activity and enzyme-substrate adaptor activity. Involved in vascular associated smooth muscle cell differentiation. Predicted to be located in nuclear body; nuclear membrane; and nucleolus. Predicted to be part of NuA4 histone acetyltransferase complex; nucleosome; and piccolo histone acetyltransferase complex. Predicted to be active in site of double-strand break. Orthologous to human EPC1 (enhancer of polycomb homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 163.9), Spleen (RPKM 127.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Epc1 in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (59198513..59289535, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (54503358..54594444, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (57303968..57394975, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene Histone deacetylase 1, pseudogene 12 Neighboring gene marker of proliferation Ki-67, pseudogene 1 Neighboring gene ral guanine nucleotide dissociation stimulator-like Neighboring gene family with sequence similarity 95 member C Neighboring gene ral guanine nucleotide dissociation stimulator-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Enhancer of polycomb1 lessens neointima formation by potentiation of myocardin-induced smooth muscle differentiation. Joung H, et al. Atherosclerosis, 2012 May. PMID 22398275
    2. Enhancer of polycomb1 acts on serum response factor to regulate skeletal muscle differentiation. Kim JR, et al. J Biol Chem, 2009 Jun 12. PMID 19359245, Free PMC Article
    3. RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions. Shimono Y, et al. J Biol Chem, 2000 Dec 15. PMID 10976108
    4. Enhancer of polycomb1, a novel homeodomain only protein-binding partner, induces skeletal muscle differentiation. Kee HJ, et al. J Biol Chem, 2007 Mar 9. PMID 17192267
    5. The INO80 family of chromatin-remodeling enzymes: regulators of histone variant dynamics. Watanabe S, et al. Cold Spring Harb Symp Quant Biol, 2010. PMID 21502417

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin-protein adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm DNA condensation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vascular associated smooth muscle cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of piccolo histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of piccolo histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    enhancer of polycomb homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309462.1 → NP_001296391.1  enhancer of polycomb homolog 1

      See identical proteins and their annotated locations for NP_001296391.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A0A8I6GEL3, A6K9H9, D4A6E4
      Related
      ENSRNOP00000019968.7, ENSRNOT00000019968.9
      Conserved Domains (2) summary
      pfam06752
      Location:531 → 762
      E_Pc_C; Enhancer of Polycomb C-terminus
      pfam10513
      Location:1 → 98
      EPL1; Enhancer of polycomb-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      59198513..59289535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095281.2 → XP_038951209.1  enhancer of polycomb homolog 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GEL3
      Conserved Domains (1) summary
      pfam06752
      Location:565 → 766
      E_Pc_C; Enhancer of Polycomb C-terminus

    2. XM_003751704.4 → XP_003751752.1  enhancer of polycomb homolog 1 isoform X2

      See identical proteins and their annotated locations for XP_003751752.1

      UniProtKB/TrEMBL
      A0A8I6G2P8, A0A8I6GEL3
      Related
      ENSRNOP00000078400.1, ENSRNOT00000117368.2
      Conserved Domains (2) summary
      pfam06752
      Location:581 → 812
      E_Pc_C; Enhancer of Polycomb C-terminus
      pfam10513
      Location:7 → 148
      EPL1; Enhancer of polycomb-like

    3. XM_063276006.1 → XP_063132076.1  enhancer of polycomb homolog 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GEL3

    4. XM_039095280.2 → XP_038951208.1  enhancer of polycomb homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GEL3
      Conserved Domains (2) summary
      pfam06752
      Location:615 → 816
      E_Pc_C; Enhancer of Polycomb C-terminus
      pfam10513
      Location:7 → 148
      EPL1; Enhancer of polycomb-like

    RNA

    1. XR_005495222.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001100972.1: Suppressed sequence

      Description
      NM_001100972.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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