Slc4a9 solute carrier family 4 member 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc4a9provided by RGD
Official Full Name: solute carrier family 4 member 9provided by RGD
Primary source: RGD:628811
See related: EnsemblRapid:ENSRNOG00000018525 AllianceGenome:RGD:628811
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ae4
Summary: Enables chloride:bicarbonate antiporter activity. Involved in monoatomic anion transport and sodium ion transmembrane transport. Located in basolateral plasma membrane. Orthologous to human SLC4A9 (solute carrier family 4 member 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 127.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 18p11

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (28402793..28418638)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (28128740..28144554)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (29352596..29373603)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D18Rat150 (e-PCR), detects polymorphism
- UniSTS:226939

AW531933 (e-PCR)
- UniSTS:245134

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chloride:bicarbonate antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables chloride:bicarbonate antiporter activity	ISO Inferred from Sequence Orthology more info
enables sodium,bicarbonate:chloride antiporter activity	IEA Inferred from Electronic Annotation more info
enables sodium,bicarbonate:chloride antiporter activity	ISO Inferred from Sequence Orthology more info
enables sodium:bicarbonate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:bicarbonate symporter activity	IEA Inferred from Electronic Annotation more info
enables sodium:bicarbonate symporter activity	ISO Inferred from Sequence Orthology more info
enables sodium:bicarbonate symporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in bicarbonate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in bicarbonate transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic anion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info
involved_in saliva secretion	IEA Inferred from Electronic Annotation more info
involved_in saliva secretion	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical part of cell	IEA Inferred from Electronic Annotation more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: anion exchange protein 4

Names: AE 4; anion exchanger 4; solute carrier family 4, sodium bicarbonate cotransporter, member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152938.2 → NP_690921.2 anion exchange protein 4

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

Q8K4V2

UniProtKB/TrEMBL

A6J313, F1LR96

Related

ENSRNOP00000025137.5, ENSRNOT00000025137.8

Conserved Domains (1) summary

cl26877
Location:53 → 908

Band_3_cyto; Band 3 cytoplasmic domain