Ogfod1 2-oxoglutarate and iron-dependent oxygenase domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ogfod1provided by RGD
Official Full Name: 2-oxoglutarate and iron-dependent oxygenase domain containing 1provided by RGD
Primary source: RGD:1308848
See related: EnsemblRapid:ENSRNOG00000019288 AllianceGenome:RGD:1308848
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1308848
Summary: Predicted to enable peptidyl-proline 3-dioxygenase activity. Predicted to be involved in several processes, including peptidyl-proline hydroxylation; regulation of translational termination; and stress granule assembly. Predicted to be located in cytoplasmic stress granule; cytosol; and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human OGFOD1 (2-oxoglutarate and iron dependent oxygenase domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 64.5), Spleen (RPKM 35.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19p12

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (10950950..10980519, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (10945031..10974602, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (11425301..11451085, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-ascorbic acid binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables peptidyl-proline 3-dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables peptidyl-proline dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-proline dioxygenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-proline hydroxylation	ISO Inferred from Sequence Orthology more info
involved_in protein hydroxylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translational termination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of translational termination	ISO Inferred from Sequence Orthology more info
involved_in stress granule assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prolyl 3-hydroxylase OGFOD1

Names: 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1

NP_001100881.1

EC 1.14.11.-

XP_063134065.1

EC 1.14.11.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.