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    Esrp2 epithelial splicing regulatory protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307810, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Esrp2provided by RGD
    Official Full Name
    epithelial splicing regulatory protein 2provided by RGD
    Primary source
    RGD:1310855
    See related
    EnsemblRapid:ENSRNOG00000023177 AllianceGenome:RGD:1310855
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rbm35b; RGD1310855
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in regulation of RNA splicing. Predicted to act upstream of or within alternative mRNA splicing, via spliceosome; morphogenesis of a branching epithelium; and positive regulation of epithelial cell proliferation. Predicted to be located in nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Orthologous to human ESRP2 (epithelial splicing regulatory protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 134.8), Thymus (RPKM 101.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Esrp2 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50944401..50951919, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (34034559..34041726, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (38113412..38120578, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene dipeptidase 2 Neighboring gene dihydrouridine synthase 2 Neighboring gene DEAD-box helicase 28 Neighboring gene nuclear factor of activated T-cells 3 Neighboring gene phospholipase A2, group XV Neighboring gene solute carrier family 7 member 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. Warzecha CC, et al. Mol Cell, 2009 Mar 13. PMID 19285943, Free PMC Article
    2. The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development. Bebee TW, et al. Elife, 2015 Sep 15. PMID 26371508, Free PMC Article
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in alternative mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in branching involved in salivary gland morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within branching involved in salivary gland morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial tube branching involved in lung morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epithelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of RNA splicing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    epithelial splicing regulatory protein 2
    Names
    RNA binding motif protein 35b
    RNA-binding motif protein 35B
    RNA-binding protein 35B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107423.1 → NP_001100893.1  epithelial splicing regulatory protein 2

      See identical proteins and their annotated locations for NP_001100893.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/TrEMBL
      A6IYV8, G3V8M2
      Related
      ENSRNOP00000026873.2, ENSRNOT00000026873.5
      Conserved Domains (4) summary
      PHA03247
      Location:555 → 678
      PHA03247; large tegument protein UL36; Provisional
      cd12742
      Location:464 → 544
      RRM3_ESRP1_ESRP2; RNA recognition motif 3 (RRM3) found in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
      cl10012
      Location:82 → 214
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
      cl17169
      Location:332 → 438
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      50944401..50951919 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006255496.5 → XP_006255558.1  epithelial splicing regulatory protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006255558.1

      UniProtKB/Swiss-Prot
      B2RYJ8
      Conserved Domains (4) summary
      PHA03247
      Location:554 → 677
      PHA03247; large tegument protein UL36; Provisional
      cd12742
      Location:463 → 543
      RRM3_ESRP1_ESRP2; RNA recognition motif 3 (RRM3) found in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
      cl10012
      Location:82 → 214
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
      cl17169
      Location:331 → 437
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_039097742.2 → XP_038953670.1  epithelial splicing regulatory protein 2 isoform X3

      Conserved Domains (4) summary
      PHA03247
      Location:564 → 687
      PHA03247; large tegument protein UL36; Provisional
      cd12742
      Location:473 → 553
      RRM3_ESRP1_ESRP2; RNA recognition motif 3 (RRM3) found in epithelial splicing regulatory protein ESRP1, ESRP2 and similar proteins
      cl10012
      Location:82 → 214
      DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
      cl17169
      Location:341 → 447
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_063278034.1 → XP_063134104.1  epithelial splicing regulatory protein 2 isoform X1

      UniProtKB/TrEMBL
      A6IYV8, G3V8M2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RYJ8.1 GenPept UniProtKB/Swiss-Prot:B2RYJ8

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