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    Lmbrd2 LMBR1 domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499539, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lmbrd2provided by RGD
    Official Full Name
    LMBR1 domain containing 2provided by RGD
    Primary source
    RGD:1563920
    See related
    EnsemblRapid:ENSRNOG00000054751 AllianceGenome:RGD:1563920
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563920
    Summary
    Predicted to be involved in adrenergic receptor signaling pathway. Predicted to be active in membrane. Orthologous to human LMBRD2 (LMBR1 domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 169.6), Kidney (RPKM 123.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lmbrd2 in Genome Data Viewer
    Location:
    2q16
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (59916736..59978739)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (58189558..58251565)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (58534474..58590767)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100736 Neighboring gene NAD kinase 2, mitochondrial Neighboring gene S-phase kinase associated protein 2 Neighboring gene UDP glycosyltransferase 3 family, polypeptide A2, pseudogene 2 Neighboring gene UDP glycosyltransferase family 3 member A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Multidimensional Tracking of GPCR Signaling via Peroxidase-Catalyzed Proximity Labeling. Paek J, et al. Cell, 2017 Apr 6. PMID 28388415, Free PMC Article
    2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in adrenergic receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adrenergic receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor-associated protein LMBRD2
    Names
    LMBR1 domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109177.1 → NP_001102647.1  G-protein coupled receptor-associated protein LMBRD2

      See identical proteins and their annotated locations for NP_001102647.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474048
      UniProtKB/TrEMBL
      A6KGJ3, D3ZUP8
      Related
      ENSRNOP00000074034.1, ENSRNOT00000077646.3
      Conserved Domains (1) summary
      pfam04791
      Location:1 → 549
      LMBR1; LMBR1-like membrane protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      59916736..59978739
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232024.5 → XP_006232086.1  G-protein coupled receptor-associated protein LMBRD2 isoform X1

      See identical proteins and their annotated locations for XP_006232086.1

      UniProtKB/TrEMBL
      A6KGJ3, D3ZUP8
      Conserved Domains (1) summary
      pfam04791
      Location:1 → 549
      LMBR1; LMBR1-like membrane protein

    2. XM_039102840.2 → XP_038958768.1  G-protein coupled receptor-associated protein LMBRD2 isoform X1

      UniProtKB/TrEMBL
      A6KGJ3, D3ZUP8
      Conserved Domains (1) summary
      pfam04791
      Location:1 → 549
      LMBR1; LMBR1-like membrane protein
    Nucleotide Protein Strain
    Heading Accession and Version

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