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    Mfsd1 major facilitator superfamily domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361957, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mfsd1provided by RGD
    Official Full Name
    major facilitator superfamily domain containing 1provided by RGD
    Primary source
    RGD:1305751
    See related
    EnsemblRapid:ENSRNOG00000013790 AllianceGenome:RGD:1305751
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305751
    Summary
    Predicted to enable dipeptide uniporter activity and protein homodimerization activity. Predicted to be involved in dipeptide transmembrane transport from lysosomal lumen to cytosol; protein localization to lysosome; and protein stabilization. Predicted to be active in lysosomal membrane. Orthologous to human MFSD1 (major facilitator superfamily domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 279.9), Spleen (RPKM 160.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mfsd1 in Genome Data Viewer
    Location:
    2q32
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (154156167..154176209)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (151846130..151866168)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (164747655..164767682)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550008 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene pyrimidinergic receptor P2Y, G-protein coupled, 4 like, pseudogene 1 Neighboring gene schwannomin interacting protein 1 Neighboring gene uncharacterized LOC102547484

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables dipeptide uniporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in dipeptide transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dipeptide transmembrane transport from lysosomal lumen to cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    major facilitator superfamily domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191847.1 → NP_001178776.1  major facilitator superfamily domain-containing protein 1

      See identical proteins and their annotated locations for NP_001178776.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I6AQT6, D3ZV75
      Related
      ENSRNOP00000018489.3, ENSRNOT00000018489.7
      Conserved Domains (2) summary
      cd06174
      Location:52 → 438
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:64 → 402
      MFS_1; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      154156167..154176209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761056.4 → XP_008759278.1  major facilitator superfamily domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_008759278.1

      UniProtKB/TrEMBL
      A0A8I6AQT6, D3ZV75
      Conserved Domains (2) summary
      cd06174
      Location:52 → 438
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:64 → 402
      MFS_1; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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