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    Sub1 SUB1 regulator of transcription [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192269, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sub1provided by RGD
    Official Full Name
    SUB1 regulator of transcriptionprovided by RGD
    Primary source
    RGD:621582
    See related
    EnsemblRapid:ENSRNOG00000067555 AllianceGenome:RGD:621582
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rpo2tc1
    Summary
    Predicted to enable several functions, including DNA binding activity; identical protein binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including RNA polymerase II promoter clearance; negative regulation of DNA duplex unwinding; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Orthologous to human SUB1 (SUB1 regulator of transcription). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 723.9), Spleen (RPKM 303.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sub1 in Genome Data Viewer
    Location:
    2q16
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (62735379..62747545, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (61005646..61020486, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (62019902..62034704, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene natriuretic peptide receptor 3 Neighboring gene uncharacterized LOC120101085 Neighboring gene uncharacterized LOC134485601 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcription reinitiation by RNA polymerase III. Dieci G, et al. Biochim Biophys Acta, 2013 Mar-Apr. PMID 23128323
    2. Molecular cloning and characterization of a cDNA clone for a protein specifically expressed in embryo as well as in a chemically induced pancreatic B cell tumor of rat. Soma G, et al. Biochem Biophys Res Commun, 1984 Oct 15. PMID 6208900
    3. Regulation of pol III transcription by nutrient and stress signaling pathways. Moir RD, et al. Biochim Biophys Acta, 2013 Mar-Apr. PMID 23165150, Free PMC Article
    4. A global transcription cofactor bound to juxtaposed strands of unwound DNA. Werten S, et al. Nat Struct Mol Biol, 2006 Feb. PMID 16415882
    5. Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes. Ge H, et al. Cell, 1994 Aug 12. PMID 8062391

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109653

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA polymerase II promoter clearance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    activated RNA polymerase II transcriptional coactivator p15
    Names
    PC4
    RNA polymerase II transcriptional coactivator
    SUB1 homolog, transcriptional regulator
    p14
    pR-ET2 encoded oncodevelopmental protein
    positive cofactor 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009618.1 → NP_001009618.1  activated RNA polymerase II transcriptional coactivator p15

      See identical proteins and their annotated locations for NP_001009618.1

      Status: PROVISIONAL

      Source sequence(s)
      BC088346
      UniProtKB/Swiss-Prot
      Q5M805, Q63396
      UniProtKB/TrEMBL
      A0A8I5ZJM1, A6KJQ6
      Related
      ENSRNOP00000092370.2, ENSRNOT00000113169.2
      Conserved Domains (1) summary
      pfam02229
      Location:68 → 115
      PC4; Transcriptional Coactivator p15 (PC4)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      62735379..62747545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232043.5 → XP_006232105.1  activated RNA polymerase II transcriptional coactivator p15 isoform X1

      See identical proteins and their annotated locations for XP_006232105.1

      UniProtKB/Swiss-Prot
      Q5M805, Q63396
      UniProtKB/TrEMBL
      A0A8I5ZJM1, A6KJQ6
      Conserved Domains (1) summary
      pfam02229
      Location:68 → 115
      PC4; Transcriptional Coactivator p15 (PC4)

    2. XM_063281272.1 → XP_063137342.1  activated RNA polymerase II transcriptional coactivator p15 isoform X1

      UniProtKB/Swiss-Prot
      Q5M805, Q63396
      UniProtKB/TrEMBL
      A0A8I5ZJM1, A6KJQ6

    3. XM_039101675.2 → XP_038957603.1  activated RNA polymerase II transcriptional coactivator p15 isoform X1

      UniProtKB/Swiss-Prot
      Q5M805, Q63396
      UniProtKB/TrEMBL
      A0A8I5ZJM1, A6KJQ6
      Conserved Domains (1) summary
      pfam02229
      Location:68 → 115
      PC4; Transcriptional Coactivator p15 (PC4)

    4. XM_039101677.2 → XP_038957605.1  activated RNA polymerase II transcriptional coactivator p15 isoform X1

      UniProtKB/Swiss-Prot
      Q5M805, Q63396
      UniProtKB/TrEMBL
      A0A8I5ZJM1, A6KJQ6
      Conserved Domains (1) summary
      pfam02229
      Location:68 → 115
      PC4; Transcriptional Coactivator p15 (PC4)

    5. XM_039101676.2 → XP_038957604.1  activated RNA polymerase II transcriptional coactivator p15 isoform X1

      UniProtKB/Swiss-Prot
      Q5M805, Q63396
      UniProtKB/TrEMBL
      A0A8I5ZJM1, A6KJQ6
      Conserved Domains (1) summary
      pfam02229
      Location:68 → 115
      PC4; Transcriptional Coactivator p15 (PC4)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63396.3 GenPept UniProtKB/Swiss-Prot:Q63396

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