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    Lamtor2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295234, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lamtor2provided by RGD
    Official Full Name
    late endosomal/lysosomal adaptor, MAPK and MTOR activator 2provided by RGD
    Primary source
    RGD:1562501
    See related
    EnsemblRapid:ENSRNOG00000019908 AllianceGenome:RGD:1562501
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Robld3; Mapbpip; RGD1562501
    Summary
    Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Predicted to be involved in several processes, including cellular response to amino acid stimulus; positive regulation of TORC1 signaling; and regulation of cell growth. Predicted to act upstream of or within several processes, including fibroblast migration; positive regulation of MAPK cascade; and regulation of cell-substrate junction organization. Predicted to be located in late endosome. Predicted to be part of FNIP-folliculin RagC/D GAP and Ragulator complex. Predicted to be active in lysosomal membrane. Orthologous to human LAMTOR2 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 634.2), Muscle (RPKM 572.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lamtor2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176306353..176310617, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174008556..174011950, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (187911530..187914930, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene mex-3 RNA binding family member A Neighboring gene RAB25, member RAS oncogene family Neighboring gene ubiquilin 4 Neighboring gene uncharacterized LOC134485638 Neighboring gene signal sequence receptor subunit 2 Neighboring gene Rho/Rac guanine nucleotide exchange factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes. Kurzbauer R, et al. Proc Natl Acad Sci U S A, 2004 Jul 27. PMID 15263099, Free PMC Article
    2. The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes. Nada S, et al. EMBO J, 2009 Mar 4. PMID 19177150, Free PMC Article
    3. Regulation of mTORC1 by amino acids. Bar-Peled L, et al. Trends Cell Biol, 2014 Jul. PMID 24698685, Free PMC Article
    4. The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration. Schiefermeier N, et al. J Cell Biol, 2014 May 26. PMID 24841562, Free PMC Article
    5. Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Bar-Peled L, et al. Cell, 2012 Sep 14. PMID 22980980, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to amino acid stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell-substrate junction organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of FNIP-folliculin RagC/D GAP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Ragulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ragulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ragulator complex protein LAMTOR2
    Names
    mitogen-activated protein binding protein interacting protein
    roadblock domain containing 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106441.1 → NP_001099911.1  ragulator complex protein LAMTOR2

      See identical proteins and their annotated locations for NP_001099911.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473976
      UniProtKB/TrEMBL
      A6J687, A6KSI4
      Related
      ENSRNOP00000109860.1, ENSRNOT00000140736.1
      Conserved Domains (1) summary
      pfam03259
      Location:5 → 95
      Robl_LC7; Roadblock/LC7 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      176306353..176310617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281607.1 → XP_063137677.1  ragulator complex protein LAMTOR2 isoform X2

      UniProtKB/TrEMBL
      A6KSI4

    2. XM_008761134.4 → XP_008759356.1  ragulator complex protein LAMTOR2 isoform X1

      UniProtKB/TrEMBL
      A6KSI4
      Conserved Domains (1) summary
      pfam03259
      Location:5 → 78
      Robl_LC7; Roadblock/LC7 domain

    3. XM_063281608.1 → XP_063137678.1  ragulator complex protein LAMTOR2 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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