U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Celsr2 cadherin, EGF LAG seven-pass G-type receptor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83465, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Celsr2provided by RGD
    Official Full Name
    cadherin, EGF LAG seven-pass G-type receptor 2provided by RGD
    Primary source
    RGD:69237
    See related
    EnsemblRapid:ENSRNOG00000020058 AllianceGenome:RGD:69237
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Megf3
    Summary
    Predicted to enable G protein-coupled receptor activity and calcium ion binding activity. Involved in dendrite morphogenesis; regulation of cell-cell adhesion; and spermatogenesis. Predicted to be located in cytoplasm and plasma membrane. Orthologous to human CELSR2 (cadherin EGF LAG seven-pass G-type receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 129.6), Brain (RPKM 79.5) and 5 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Celsr2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (198717333..198741689, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (196029206..196053848, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (211183410..211207458, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene myosin binding protein H-like Neighboring gene uncharacterized LOC134485672 Neighboring gene proline and serine rich coiled-coil 1 Neighboring gene uncharacterized LOC108350091 Neighboring gene seryl-tRNA synthetase 1 Neighboring gene small nucleolar RNA SNORA70

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Silencing Celsr2 inhibits the proliferation and migration of Schwann cells through suppressing the Wnt/β-catenin signaling pathway. Zhou X, et al. Biochem Biophys Res Commun, 2020 Dec 17. PMID 32988580
    2. Mono-(2-ethylhexyl) phthalate rapidly increases celsr2 protein phosphorylation in HeLa cells via protein kinase C and casein kinase 1. Lahousse SA, et al. Toxicol Sci, 2006 May. PMID 16484285
    3. Hybrid GPCR/cadherin (Celsr) proteins in rat testis are expressed with cell type specificity and exhibit differential Sertoli cell-germ cell adhesion activity. Beall SA, et al. J Androl, 2005 Jul-Aug. PMID 15955893
    4. Regulation of dendritic maintenance and growth by a mammalian 7-pass transmembrane cadherin. Shima Y, et al. Dev Cell, 2004 Aug. PMID 15296717
    5. Opposing roles in neurite growth control by two seven-pass transmembrane cadherins. Shima Y, et al. Nat Neurosci, 2007 Aug. PMID 17618280

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Silencing Celsr2 inhibits the proliferation and migration of Schwann cells through suppressing the Wnt/beta-catenin signaling pathway.
      Title: Silencing Celsr2 inhibits the proliferation and migration of Schwann cells through suppressing the Wnt/β-catenin signaling pathway.
    2. The Celsr2 enhanced neurite growth of neuron in hippocampus of rat.
      Title: Opposing roles in neurite growth control by two seven-pass transmembrane cadherins.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cerebrospinal fluid secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cerebrospinal fluid secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cilium movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in motor neuron migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within motor neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neural plate anterior/posterior regionalization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neural plate anterior/posterior regionalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in ventricular system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ventricular system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    cadherin EGF LAG seven-pass G-type receptor 2
    Names
    Flamingo1
    cadherin EGF LAG seven-pas G-type receptor 2
    cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)
    flamingo-like protein celsr2
    multiple EGF-like domains protein 3
    multiple epidermal growth factor-like domains 3
    multiple epidermal growth factor-like domains protein 3
    seven-pass transmembrane cadherin

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191110.1 → NP_001178039.1  cadherin EGF LAG seven-pass G-type receptor 2 precursor

      See identical proteins and their annotated locations for NP_001178039.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6HV01, G3V8P3
      Related
      ENSRNOP00000101341.1, ENSRNOT00000168722.1
      Conserved Domains (10) summary
      smart00303
      Location:2315 → 2368
      GPS; G-protein-coupled receptor proteolytic site domain
      cd11304
      Location:404 → 501
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00008
      Location:1972 → 2034
      HormR; Domain present in hormone receptors
      smart00180
      Location:1924 → 1969
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00054
      Location:1289 → 1324
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:1369 → 1552
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam01500
      Location:1806 → 1956
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam16489
      Location:2052 → 2287
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl19567
      Location:1819 → 1866
      DSL; Delta serrate ligand
      cl21561
      Location:2374 → 2605
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      198717333..198741689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103241.2 → XP_038959169.1  cadherin EGF LAG seven-pass G-type receptor 2 isoform X3

      UniProtKB/TrEMBL
      G3V8P3
      Related
      ENSRNOP00000106325.1, ENSRNOT00000132314.1

    2. XM_006233192.5 → XP_006233254.1  cadherin EGF LAG seven-pass G-type receptor 2 isoform X1

      UniProtKB/TrEMBL
      G3V8P3
      Related
      ENSRNOP00000027263.7, ENSRNOT00000027263.8
      Conserved Domains (10) summary
      smart00303
      Location:2315 → 2368
      GPS; G-protein-coupled receptor proteolytic site domain
      cd11304
      Location:404 → 501
      Cadherin_repeat; Cadherin tandem repeat domain
      smart00008
      Location:1972 → 2034
      HormR; Domain present in hormone receptors
      smart00180
      Location:1924 → 1969
      EGF_Lam; Laminin-type epidermal growth factor-like domai
      cd00054
      Location:1289 → 1324
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:1369 → 1552
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam01500
      Location:1806 → 1956
      Keratin_B2; Keratin, high sulfur B2 protein
      pfam16489
      Location:2052 → 2287
      GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
      cl19567
      Location:1819 → 1866
      DSL; Delta serrate ligand
      cl21561
      Location:2374 → 2605
      7tm_4; Olfactory receptor

    3. XM_017591134.3 → XP_017446623.1  cadherin EGF LAG seven-pass G-type receptor 2 isoform X2

      UniProtKB/TrEMBL
      G3V8P3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_031319.1: Suppressed sequence

      Description
      NM_031319.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QYP2.1 GenPept UniProtKB/Swiss-Prot:Q9QYP2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools