Kpna5 karyopherin subunit alpha 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kpna5provided by RGD
Official Full Name: karyopherin subunit alpha 5provided by RGD
Primary source: RGD:1561324
See related: EnsemblRapid:ENSRNOG00000030109 AllianceGenome:RGD:1561324
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ipoa6
Summary: Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to be located in cytosol. Predicted to be active in nucleoplasm. Orthologous to human KPNA5 (karyopherin subunit alpha 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 75.1), Spleen (RPKM 74.7) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 20q11

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (31365647..31430793)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (30822925..30888080)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (32509573..32573591)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear import signal receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: importin subunit alpha-6

Names: karyopherin alpha 5 (importin alpha 6)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025113.3 → NP_001020284.2 importin subunit alpha-6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

A0A0H2UHW5, Q56R16

UniProtKB/TrEMBL

A0A8I6APC5

Related

ENSRNOP00000079511.1, ENSRNOT00000097623.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

31365647..31430793

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098595.2 → XP_038954523.1 importin subunit alpha-6 isoform X2

Conserved Domains (2) summary

COG5064
Location:36 → 251

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:122 → 155

ARM; armadillo repeat [structural motif]
XM_008772879.3 → XP_008771101.1 importin subunit alpha-6 isoform X1

UniProtKB/TrEMBL

A0A8I6APC5

Conserved Domains (2) summary

COG5064
Location:5 → 446

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

sd00043
Location:175 → 200

ARM; armadillo repeat [structural motif]