Tapbp TAP binding protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tapbpprovided by RGD
Official Full Name: TAP binding proteinprovided by RGD
Primary source: RGD:3819
See related: EnsemblRapid:ENSRNOG00000029500 AllianceGenome:RGD:3819
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including MHC class I protein complex binding activity; TAP binding activity; and TAP complex binding activity. Involved in MHC class I protein complex assembly. Part of MHC class I peptide loading complex. Human ortholog(s) of this gene implicated in severe combined immunodeficiency. Orthologous to human TAPBP (TAP binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 490.3), Adrenal (RPKM 350.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (4958821..4967958, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (4956937..4966191, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (5468056..5476007, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that expression levels of tapasin and the immunoproteasome components MECL-1, PA28-alpha, and PA28-beta are lower in Ad12- than in Ad5-transformed BRK cells.
Title: Differential expression of tapasin and immunoproteasome subunits in adenovirus type 5- versus type 12-transformed cells.

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:237624 (e-PCR)
- UniSTS:237624

BF390203 (e-PCR)
- UniSTS:249412

Zfp297 (e-PCR), detects polymorphism
- UniSTS:463439

BE106728 (e-PCR)
- UniSTS:246398

RH130697 (e-PCR)
- UniSTS:213981

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MHC class I protein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables TAP complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables TAP complex binding	ISO Inferred from Sequence Orthology more info
enables TAP1 binding	ISO Inferred from Sequence Orthology more info
enables TAP2 binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein folding chaperone	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in MHC class I protein complex assembly	IEP Inferred from Expression Pattern more info	PubMed
involved_in MHC class Ib protein complex assembly	ISO Inferred from Sequence Orthology more info
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	ISO Inferred from Sequence Orthology more info
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response	ISO Inferred from Sequence Orthology more info
involved_in peptide antigen assembly with MHC class I protein complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptide antigen assembly with MHC class I protein complex	ISO Inferred from Sequence Orthology more info
involved_in peptide antigen stabilization	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein complex stability	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
part_of MHC class I peptide loading complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MHC class I peptide loading complex	IDA Inferred from Direct Assay more info	PubMed
part_of MHC class I peptide loading complex	ISO Inferred from Sequence Orthology more info
part_of Tapasin-ERp57 complex	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tapasin

Names: Tap-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.