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    Armc2 armadillo repeat containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499470, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Armc2provided by RGD
    Official Full Name
    armadillo repeat containing 2provided by RGD
    Primary source
    RGD:1562413
    See related
    EnsemblRapid:ENSRNOG00000026217 AllianceGenome:RGD:1562413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562413
    Summary
    Predicted to be involved in sperm axoneme assembly. Predicted to act upstream of or within flagellated sperm motility and spermatogenesis. Human ortholog(s) of this gene implicated in spermatogenic failure 38. Orthologous to human ARMC2 (armadillo repeat containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 43.6), Heart (RPKM 31.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Armc2 in Genome Data Viewer
    Location:
    20q12
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (46976442..47083888, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (45395859..45501808, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (46766467..46872009, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene centrosomal protein 57-like 1 Neighboring gene sestrin 1 Neighboring gene uncharacterized LOC103694446 Neighboring gene uncharacterized LOC134483825

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Bi-allelic Mutations in ARMC2 Lead to Severe Astheno-Teratozoospermia Due to Sperm Flagellum Malformations in Humans and Mice. Coutton C, et al. Am J Hum Genet, 2019 Feb 7. PMID 30686508, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleus organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nucleus organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm axoneme assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    armadillo repeat containing 2; armadillo repeat-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432282.1 → NP_001419211.1  armadillo repeat containing 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020

    2. NM_001432283.1 → NP_001419212.1  armadillo repeat containing 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      D4AE64

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      46976442..47083888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_574794.5 → XP_574794.3  armadillo repeat-containing protein 2 isoform X1

      Related
      ENSRNOP00000033465.5, ENSRNOT00000031047.9
      Conserved Domains (2) summary
      cd00020
      Location:698 → 818
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      sd00043
      Location:734 → 774
      ARM; armadillo repeat [structural motif]

    2. XM_039099142.2 → XP_038955070.1  armadillo repeat-containing protein 2 isoform X2

      Conserved Domains (1) summary
      sd00043
      Location:640 → 680
      ARM; armadillo repeat [structural motif]

    3. XM_063279680.1 → XP_063135750.1  armadillo repeat-containing protein 2 isoform X3

      UniProtKB/TrEMBL
      A6K6Z7

    RNA

    1. XR_005497350.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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