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    Spred1 sprouty-related, EVH1 domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296072, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spred1provided by RGD
    Official Full Name
    sprouty-related, EVH1 domain containing 1provided by RGD
    Primary source
    RGD:1308735
    See related
    EnsemblRapid:ENSRNOG00000070996 AllianceGenome:RGD:1308735
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme binding activity; protein serine/threonine kinase inhibitor activity; and stem cell factor receptor binding activity. Predicted to be involved in several processes, including negative regulation of cell differentiation; regulation of protein modification process; and regulation of signal transduction. Predicted to act upstream of or within negative regulation of MAPK cascade. Located in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in Legius syndrome. Orthologous to human SPRED1 (sprouty related EVH1 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 163.5), Lung (RPKM 156.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Spred1 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (124437230..124504358)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (103983120..104050321)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (108795337..108861650)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486426 Neighboring gene transmembrane and coiled-coil domains 5A Neighboring gene small nucleolar RNA U13 Neighboring gene enolase 1, pseudogene 25 Neighboring gene microRNA 674 Neighboring gene family with sequence similarity 98, member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of Sproutys and SPREDs is decreased during lung branching morphogenesis in nitrofen-induced pulmonary hypoplasia. Friedmacher F, et al. Pediatr Surg Int, 2013 Nov. PMID 23982388
    2. MicroRNA-1 enhances the angiogenic differentiation of human cardiomyocyte progenitor cells. van Mil A, et al. J Mol Med (Berl), 2013 Aug. PMID 23625462
    3. Loss of angiomiR-126 and 130a in angiogenic early outgrowth cells from patients with chronic heart failure: role for impaired in vivo neovascularization and cardiac repair capacity. Jakob P, et al. Circulation, 2012 Dec 18. PMID 23136161
    4. Sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain-containing protein (SPRED1), a tyrosine-protein phosphatase non-receptor type 11 (SHP2) substrate in the Ras/extracellular signal-regulated kinase (ERK) pathway. Quintanar-Audelo M, et al. J Biol Chem, 2011 Jul 1. PMID 21531714, Free PMC Article
    5. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Wang S, et al. Dev Cell, 2008 Aug. PMID 18694565, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Decreased expression of Sproutys and SPREDs during the terminal pseudoglandular stage may disrupt lung branching morphogenesis by interfering with epithelial-mesenchymal interactions contributing to PH.
      Title: Expression of Sproutys and SPREDs is decreased during lung branching morphogenesis in nitrofen-induced pulmonary hypoplasia.
    2. SPRED1 is a likely substrate of SHP2, whose tyrosine dephosphorylation is required to attenuate the inhibitory action of SPRED1 in the Ras/ERK pathway.
      Title: Sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain-containing protein (SPRED1), a tyrosine-protein phosphatase non-receptor type 11 (SHP2) substrate in the Ras/extracellular signal-regulated kinase (ERK) pathway.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables stem cell factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of lens fiber cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein deacetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vasculogenesis involved in coronary vascular morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sprouty-related, EVH1 domain-containing protein 1
    Names
    sprouty protein with EVH-1 domain 1, related sequence

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047089.2 → NP_001040554.1  sprouty-related, EVH1 domain-containing protein 1

      See identical proteins and their annotated locations for NP_001040554.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZRI8, A0A8I6AJF5, A6HP93, Q3C2P9
      Related
      ENSRNOP00000095328.1, ENSRNOT00000096496.2
      Conserved Domains (2) summary
      cd10574
      Location:13 → 125
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:333 → 428
      Sprouty; Sprouty protein (Spry)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      124437230..124504358
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104539.2 → XP_038960467.1  sprouty-related, EVH1 domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZRI8
      Conserved Domains (2) summary
      cd10574
      Location:1 → 104
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:311 → 407
      Sprouty; Sprouty protein (Spry)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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