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    Ccdc146 coiled-coil domain containing 146 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499980, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccdc146provided by RGD
    Official Full Name
    coiled-coil domain containing 146provided by RGD
    Primary source
    RGD:1559535
    See related
    EnsemblRapid:ENSRNOG00000012932 AllianceGenome:RGD:1559535
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in manchette assembly and sperm axoneme assembly. Predicted to act upstream of or within several processes, including flagellated sperm motility; single fertilization; and spermatogenesis. Predicted to be located in several cellular components, including microtubule organizing center; midbody; and sperm head-tail coupling apparatus. Predicted to be active in cytoskeleton. Human ortholog(s) of this gene implicated in spermatogenic failure 94. Orthologous to human CCDC146 (coiled-coil domain containing 146). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 54.8), Lung (RPKM 45.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccdc146 in Genome Data Viewer
    Location:
    4q11
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (14554966..14703801)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (13662766..13811619)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (10269798..10421724)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene F-box and leucine-rich repeat protein 13 Neighboring gene small nucleolar RNA SNORD86 Neighboring gene uncharacterized LOC134486551 Neighboring gene family with sequence similarity 185, member A Neighboring gene uncharacterized LOC120102212 Neighboring gene fibrinogen-like 2 Neighboring gene gamma-secretase activating protein Neighboring gene neuroepithelial cell transforming 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Proteomic analysis of mammalian sperm cells identifies new components of the centrosome. Firat-Karalar EN, et al. J Cell Sci, 2014 Oct 1. PMID 25074808, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cilium organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in manchette assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within manchette assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in manchette assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nucleus organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within nucleus organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in single fertilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within single fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm axoneme assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sperm axoneme assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within sperm flagellum assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm flagellum assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axoneme IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axoneme ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in sperm flagellum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in sperm head-tail coupling apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sperm head-tail coupling apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 146

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025044.1 → NP_001020215.1  coiled-coil domain-containing protein 146

      See identical proteins and their annotated locations for NP_001020215.1

      Status: VALIDATED

      Source sequence(s)
      BC082003
      UniProtKB/Swiss-Prot
      Q66H60
      UniProtKB/TrEMBL
      A6K5B9
      Related
      ENSRNOP00000017374.7, ENSRNOT00000017374.8
      Conserved Domains (1) summary
      COG1196
      Location:87 → 900
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. NM_001419502.1 → NP_001406431.1  coiled-coil domain-containing protein 146

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q66H60
      UniProtKB/TrEMBL
      A6K5B9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      14554966..14703801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108085.2 → XP_038964013.1  coiled-coil domain-containing protein 146 isoform X1

      UniProtKB/Swiss-Prot
      Q66H60
      UniProtKB/TrEMBL
      A6K5B9
      Conserved Domains (1) summary
      COG1196
      Location:87 → 900
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_039108087.2 → XP_038964015.1  coiled-coil domain-containing protein 146 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G2F7, A6K5B9
      Related
      ENSRNOP00000078848.1, ENSRNOT00000105791.2
      Conserved Domains (1) summary
      COG1196
      Location:87 → 871
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    3. XM_039108089.2 → XP_038964017.1  coiled-coil domain-containing protein 146 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZYI6, A6K5B9
      Related
      ENSRNOP00000084247.1, ENSRNOT00000097474.2
      Conserved Domains (2) summary
      COG1196
      Location:74 → 443
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      NF033930
      Location:496 → 701
      pneumo_PspA; pneumococcal surface protein A

    4. XM_039108088.2 → XP_038964016.1  coiled-coil domain-containing protein 146 isoform X3

      UniProtKB/TrEMBL
      A0A8I6GH17, A6K5B9
      Related
      ENSRNOP00000089235.1, ENSRNOT00000103228.2
      Conserved Domains (2) summary
      COG1196
      Location:82 → 824
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:196 → 466
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    5. XM_039108090.2 → XP_038964018.1  coiled-coil domain-containing protein 146 isoform X5

      UniProtKB/TrEMBL
      A6K5B9
      Conserved Domains (1) summary
      COG1196
      Location:267 → 594
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    6. XM_039108086.2 → XP_038964014.1  coiled-coil domain-containing protein 146 isoform X1

      UniProtKB/Swiss-Prot
      Q66H60
      UniProtKB/TrEMBL
      A6K5B9
      Conserved Domains (1) summary
      COG1196
      Location:87 → 900
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    7. XM_063286464.1 → XP_063142534.1  coiled-coil domain-containing protein 146 isoform X6

    RNA

    1. XR_005503289.2 RNA Sequence

    2. XR_005503288.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66H60.1 GenPept UniProtKB/Swiss-Prot:Q66H60

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials