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    Rbm28 RNA binding motif protein 28 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312182, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbm28provided by RGD
    Official Full Name
    RNA binding motif protein 28provided by RGD
    Primary source
    RGD:1311336
    See related
    EnsemblRapid:ENSRNOG00000005468 AllianceGenome:RGD:1311336
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA binding activity. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in alopecia, neurologic defects, and endocrinopathy syndrome. Orthologous to human RBM28 (RNA binding motif protein 28). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 48.2), Thymus (RPKM 47.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rbm28 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (58688337..58727312, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (57722946..57761935, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (56398769..56438442, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102250 Neighboring gene microRNA 129-1 Neighboring gene leptin Neighboring gene proline-rich transmembrane protein 4 Neighboring gene inosine monophosphate dehydrogenase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing. Sloan KE, et al. J Cell Biol, 2013 Mar 4. PMID 23439679, Free PMC Article
    2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 28

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107850.2 → NP_001101320.1  RNA-binding protein 28 isoform 1

      See identical proteins and their annotated locations for NP_001101320.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2JVD0, A6IEB7
      Related
      ENSRNOP00000069435.1, ENSRNOT00000077079.3
      Conserved Domains (5) summary
      cd12413
      Location:5 → 78
      RRM1_RBM28_like; RNA recognition motif 1 in RNA-binding protein 28 (RBM28) and similar proteins
      cd12414
      Location:115 → 190
      RRM2_RBM28_like; RNA recognition motif 2 in RNA-binding protein 28 (RBM28) and similar proteins
      cd12415
      Location:329 → 411
      RRM3_RBM28_like; RNA recognition motif 3 in RNA-binding protein 28 (RBM28) and similar proteins
      cd12416
      Location:458 → 522
      RRM4_RBM28_like; RNA recognition motif 4 in RNA-binding protein 28 (RBM28) and similar proteins
      TIGR01661
      Location:6 → 408
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    2. NM_001415878.1 → NP_001402807.1  RNA-binding protein 28 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      58688337..58727312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107509.2 → XP_038963437.1  RNA-binding protein 28 isoform X2

      UniProtKB/TrEMBL
      D4A5K7
      Related
      ENSRNOP00000059579.3, ENSRNOT00000064007.5
      Conserved Domains (5) summary
      TIGR01628
      Location:303 → 690
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      COG0724
      Location:33 → 202
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12414
      Location:96 → 171
      RRM2_RBM28_like; RNA recognition motif 2 (RRM2) found in RNA-binding protein 28 (RBM28) and similar proteins
      cd12415
      Location:310 → 392
      RRM3_RBM28_like; RNA recognition motif 3 (RRM3) found in RNA-binding protein 28 (RBM28) and similar proteins
      cd12416
      Location:462 → 556
      RRM4_RBM28_like; RNA recognition motif 4 (RRM4) found in RNA-binding protein 28 (RBM28) and similar proteins

    2. XM_006236190.5 → XP_006236252.1  RNA-binding protein 28 isoform X1

      UniProtKB/TrEMBL
      D4A5K7
      Conserved Domains (6) summary
      TIGR01628
      Location:322 → 709
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12413
      Location:5 → 78
      RRM1_RBM28_like; RNA recognition motif 1 in RNA-binding protein 28 (RBM28) and similar proteins
      cd12414
      Location:115 → 190
      RRM2_RBM28_like; RNA recognition motif 2 in RNA-binding protein 28 (RBM28) and similar proteins
      cd12415
      Location:329 → 411
      RRM3_RBM28_like; RNA recognition motif 3 in RNA-binding protein 28 (RBM28) and similar proteins
      cd12416
      Location:481 → 575
      RRM4_RBM28_like; RNA recognition motif 4 in RNA-binding protein 28 (RBM28) and similar proteins
      TIGR01661
      Location:6 → 408
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    Nucleotide Protein Strain
    Heading Accession and Version

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