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    Hoxa4 homeo box A4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100912525, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hoxa4provided by RGD
    Official Full Name
    homeo box A4provided by RGD
    Primary source
    RGD:2814
    See related
    EnsemblRapid:ENSRNOG00000027365 AllianceGenome:RGD:2814
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hox1r2; hox1.4
    Summary
    The protein encoded by this gene is likely a homeobox transcription factor. [provided by RefSeq, Sep 2015]
    Expression
    Biased expression in Lung (RPKM 23.9), Kidney (RPKM 18.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hoxa4 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (82620294..82622302, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (81289677..81291685, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (82158234..82160317, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene homeobox A2 Neighboring gene homeobox A3 Neighboring gene homeobox A3 like 1 Neighboring gene uncharacterized LOC120102276 Neighboring gene Hoxa cluster antisense RNA 3 Neighboring gene homeo box A5 Neighboring gene homeobox A6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and expression of rat homeo-box-containing sequences. Falzon M, et al. Gene, 1987. PMID 2886401
    2. Cloning and sequence analysis of homeobox transcription factor cDNAs with an inosine-containing probe. Gorski DH, et al. Biotechniques, 1994 May. PMID 7915120
    3. Cloning of rat homeobox genes. Sakoyama Y, et al. Biochem Genet, 1994 Oct. PMID 7702549
    4. Functional comparison of the Hoxa 4, Hoxa 10, and Hoxa 11 homeoboxes. Zhao Y, et al. Dev Biol, 2002 Apr 1. PMID 11900456
    5. Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed. Horan GS, et al. Genes Dev, 1995 Jul 1. PMID 7628700

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior pattern specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic skeletal system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein Hox-A4
    Names
    Homeobox gene A4
    homeobox A4-like
    homeobox protein Hox-A4-like
    homeobox protein R2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024350.1 → NP_077326.1  homeobox protein Hox-A4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      E9PT77
      Related
      ENSRNOP00000035732.2, ENSRNOT00000038775.6
      Conserved Domains (1) summary
      pfam00046
      Location:183 → 236
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      82620294..82622302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09635.1 GenPept UniProtKB/Swiss-Prot:P09635

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.