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    Clspn claspin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298534, updated on 9-Dec-2024

    Summary

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    Symbol
    Clspnprovided by RGD
    Full Name
    claspinprovided by RGD
    Primary source
    RGD:1309083
    See related
    EnsemblRapid:ENSRNOG00000011332 AllianceGenome:RGD:1309083
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA secondary structure binding activity and anaphase-promoting complex binding activity. Predicted to be involved in activation of protein kinase activity; mitotic G2/M transition checkpoint; and peptidyl-serine phosphorylation. Predicted to be located in Golgi apparatus and nucleoplasm. Orthologous to human CLSPN (claspin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 56.1), Spleen (RPKM 41.7) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Clspn in Genome Data Viewer
    Location:
    5q36
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (144134619..144169531)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (138850119..138885037)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (144577670..144617507)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene argonaute RISC component 4 Neighboring gene atherin-like Neighboring gene similar to human chromosome 1 open reading frame 216 Neighboring gene uncharacterized LOC120102980 Neighboring gene proteasome 20S subunit beta 2 Neighboring gene transcription factor AP-2 epsilon

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. [Inlays in the prosthetic rehabilitation of the periodontal patient]. Calderari G. Dent Cadmos, 1966 Nov. PMID 5226314
    2. Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function. Chini CC, et al. J Biol Chem, 2006 Nov 3. PMID 16963448
    3. Human claspin is required for replication checkpoint control. Chini CC, et al. J Biol Chem, 2003 Aug 8. PMID 12766152
    4. SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response. Peschiaroli A, et al. Mol Cell, 2006 Aug 4. PMID 16885022
    5. The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. Bassermann F, et al. Cell, 2008 Jul 25. PMID 18662541, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA secondary structure binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables anaphase-promoting complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables anaphase-promoting complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of DNA replication checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA replication checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic G2 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    claspin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395082.1 → NP_001382011.1  claspin

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6ISB0, D3ZHC3
      Related
      ENSRNOP00000015227.6, ENSRNOT00000015227.7
      Conserved Domains (2) summary
      PTZ00341
      Location:1043 → 1178
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      PTZ00108
      Location:15 → 222
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      144134619..144169531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238864.5 → XP_006238926.1  claspin isoform X1

      See identical proteins and their annotated locations for XP_006238926.1

      UniProtKB/TrEMBL
      A6ISB0, D3ZHC3
      Conserved Domains (2) summary
      PTZ00341
      Location:1043 → 1178
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      PTZ00108
      Location:15 → 222
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    2. XM_006238863.5 → XP_006238925.1  claspin isoform X1

      See identical proteins and their annotated locations for XP_006238925.1

      UniProtKB/TrEMBL
      A6ISB0, D3ZHC3
      Conserved Domains (2) summary
      PTZ00341
      Location:1043 → 1178
      PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
      PTZ00108
      Location:15 → 222
      PTZ00108; DNA topoisomerase 2-like protein; Provisional

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106687.1: Suppressed sequence

      Description
      NM_001106687.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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