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    Dcaf4 DDB1 and CUL4 associated factor 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362762, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dcaf4provided by RGD
    Official Full Name
    DDB1 and CUL4 associated factor 4provided by RGD
    Primary source
    RGD:1306241
    See related
    EnsemblRapid:ENSRNOG00000008399 AllianceGenome:RGD:1306241
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wdr21
    Summary
    Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Orthologous to several human genes including DCAF4 (DDB1 and CUL4 associated factor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 63.0), Adrenal (RPKM 53.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dcaf4 in Genome Data Viewer
    Location:
    6q31
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (108885970..108912116)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (103154847..103180992)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (107001763..107027466)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene regulator of G-protein signaling 6 Neighboring gene uncharacterized LOC120093217 Neighboring gene double PHD fingers 3 Neighboring gene uncharacterized LOC134479225 Neighboring gene uncharacterized LOC134479227 Neighboring gene uncharacterized LOC134479226 Neighboring gene uncharacterized LOC102547293 Neighboring gene zinc finger FYVE-type containing 1 Neighboring gene RNA binding motif protein 25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Jin J, et al. Mol Cell, 2006 Sep 1. PMID 16949367
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DDB1- and CUL4-associated factor 4
    Names
    WD repeat domain 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108716.1 → NP_001102186.1  DDB1- and CUL4-associated factor 4

      See identical proteins and their annotated locations for NP_001102186.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473982
      UniProtKB/TrEMBL
      A6JDQ0
      Conserved Domains (3) summary
      COG2319
      Location:301 → 470
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:285 → 323
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:313 → 470
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      108885970..108912116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240347.5 → XP_006240409.1  DDB1- and CUL4-associated factor 4 isoform X1

      UniProtKB/TrEMBL
      D4A7F7
      Related
      ENSRNOP00000011378.6, ENSRNOT00000011378.8
      Conserved Domains (3) summary
      COG2319
      Location:302 → 471
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:286 → 324
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:314 → 471
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_063262119.1 → XP_063118189.1  DDB1- and CUL4-associated factor 4 isoform X2

    3. XM_039112513.1 → XP_038968441.1  DDB1- and CUL4-associated factor 4 isoform X3

      Conserved Domains (2) summary
      sd00039
      Location:71 → 109
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:96 → 256
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version

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