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    Kcng3 potassium voltage-gated channel modifier subfamily G member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171011, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kcng3provided by RGD
    Official Full Name
    potassium voltage-gated channel modifier subfamily G member 3provided by RGD
    Primary source
    RGD:628832
    See related
    EnsemblRapid:ENSRNOG00000004535 AllianceGenome:RGD:628832
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kv6.3; Kv10.1
    Summary
    Enables potassium channel regulator activity. Acts upstream of or within regulation of potassium ion transport. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Orthologous to human KCNG3 (potassium voltage-gated channel modifier subfamily G member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 28.1), Brain (RPKM 18.9) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kcng3 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (16803842..16851791)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (11051311..11099264)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (6794808..6842758, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene metastasis associated 1 family, member 3 Neighboring gene uncharacterized LOC134479096 Neighboring gene uncharacterized LOC134479097 Neighboring gene uncharacterized LOC120093197

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of Kv6.3, a novel modulatory subunit for voltage-gated K(+) channel Kv2.1. Sano Y, et al. FEBS Lett, 2002 Feb 13. PMID 11852086
    2. Modification of Kv2.1 K+ currents by the silent Kv10 subunits. Vega-Saenz de Miera EC. Brain Res Mol Brain Res, 2004 Apr 7. PMID 15046870
    3. Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome. Ottschytsch N, et al. Proc Natl Acad Sci U S A, 2002 Jun 11. PMID 12060745, Free PMC Article
    4. Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4. Mederos Y Schnitzler M, et al. J Biol Chem, 2009 Feb 13. PMID 19074135
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4.
      Title: Mutation of histidine 105 in the T1 domain of the potassium channel Kv2.1 disrupts heteromerization with Kv6.3 and Kv6.4.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel regulator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of potassium ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of potassium ion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of potassium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    voltage-gated potassium channel regulatory subunit KCNG3
    Names
    potassium channel, voltage gated modifier subfamily G, member 3
    potassium voltage-gated channel, subfamily G, member 3
    potassium voltage-gated channel, subfamily G, memeber 3
    voltage-gated potassium channel 6.3
    voltage-gated potassium channel subunit Kv10.1
    voltage-gated potassium channel subunit Kv6.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033957.1 → NP_001029129.1  voltage-gated potassium channel regulatory subunit KCNG3 isoform 2

      See identical proteins and their annotated locations for NP_001029129.1

      Status: VALIDATED

      Source sequence(s)
      AF454549
      UniProtKB/Swiss-Prot
      Q8R523
      Conserved Domains (4) summary
      smart00225
      Location:11 → 119
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:202 → 406
      Ion_trans; Ion transport protein
      pfam07885
      Location:349 → 394
      Ion_trans_2; Ion channel
      cl02518
      Location:11 → 111
      BTB; BTB/POZ domain

    2. NM_133426.2 → NP_596917.2  voltage-gated potassium channel regulatory subunit KCNG3 isoform 1

      See identical proteins and their annotated locations for NP_596917.2

      Status: VALIDATED

      Source sequence(s)
      AF454550
      UniProtKB/Swiss-Prot
      Q8R523
      Related
      ENSRNOP00000006094.4, ENSRNOT00000006094.8
      Conserved Domains (4) summary
      smart00225
      Location:11 → 119
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:216 → 417
      Ion_trans; Ion transport protein
      pfam07885
      Location:360 → 405
      Ion_trans_2; Ion channel
      cl02518
      Location:11 → 111
      BTB; BTB/POZ domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      16803842..16851791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R523.2 GenPept UniProtKB/Swiss-Prot:Q8R523

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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