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    Arhgap9 Rho GTPase activating protein 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362893, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arhgap9provided by RGD
    Official Full Name
    Rho GTPase activating protein 9provided by RGD
    Primary source
    RGD:1305342
    See related
    EnsemblRapid:ENSRNOG00000006946 AllianceGenome:RGD:1305342
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GTPase activator activity and phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human ARHGAP9 (Rho GTPase activating protein 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 197.0), Spleen (RPKM 155.6) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arhgap9 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (65034023..65042336)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (63148573..63157025)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (70612650..70620900)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene DDIT3 upstream open reading frame protein Neighboring gene DNA-damage inducible transcript 3 Neighboring gene methionyl-tRNA synthetase 1 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 23 Neighboring gene GLI family zinc finger 1 Neighboring gene inhibin subunit beta E Neighboring gene uncharacterized LOC120093804 Neighboring gene inhibin subunit beta C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Non-canonical interaction of phosphoinositides with pleckstrin homology domains of Tiam1 and ArhGAP9. Ceccarelli DF, et al. J Biol Chem, 2007 May 4. PMID 17339315
    2. Isolation of a novel human gene, ARHGAP9, encoding a rho-GTPase activating protein. Furukawa Y, et al. Biochem Biophys Res Commun, 2001 Jun 15. PMID 11396949
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125000

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in small GTPase-mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho GTPase-activating protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012198.2 → NP_001012198.1  rho GTPase-activating protein 9 isoform 2

      See identical proteins and their annotated locations for NP_001012198.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      Q6AXS7
      Conserved Domains (3) summary
      cd13233
      Location:46 → 159
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:60 → 158
      PH; PH domain
      cl02570
      Location:248 → 402
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    2. NM_001080789.2 → NP_001074258.1  rho GTPase-activating protein 9 isoform 1

      See identical proteins and their annotated locations for NP_001074258.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      F7FH17, Q32PX8
      Related
      ENSRNOP00000036104.6, ENSRNOT00000035382.7
      Conserved Domains (4) summary
      cd13233
      Location:227 → 340
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:241 → 339
      PH; PH domain
      cl02570
      Location:429 → 583
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl17036
      Location:27 → 82
      SH3; Src Homology 3 domain superfamily

    3. NM_001414956.1 → NP_001401885.1  rho GTPase-activating protein 9 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      65034023..65042336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241466.4 → XP_006241528.1  rho GTPase-activating protein 9 isoform X3

      UniProtKB/TrEMBL
      F7FH17
      Conserved Domains (4) summary
      cd13233
      Location:227 → 340
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:241 → 339
      PH; PH domain
      cl02570
      Location:432 → 586
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl17036
      Location:27 → 82
      SH3; Src Homology 3 domain superfamily

    2. XM_006241465.4 → XP_006241527.1  rho GTPase-activating protein 9 isoform X2

      UniProtKB/TrEMBL
      F7EUE3
      Conserved Domains (4) summary
      cd04403
      Location:429 → 633
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:227 → 340
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:241 → 339
      PH; PH domain
      cl17036
      Location:27 → 82
      SH3; Src Homology 3 domain superfamily

    3. XM_006241467.4 → XP_006241529.1  rho GTPase-activating protein 9 isoform X4

      UniProtKB/TrEMBL
      F7FH17
      Conserved Domains (4) summary
      cd13233
      Location:227 → 340
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:241 → 339
      PH; PH domain
      cl02570
      Location:432 → 550
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl17036
      Location:27 → 82
      SH3; Src Homology 3 domain superfamily

    4. XM_006241464.5 → XP_006241526.1  rho GTPase-activating protein 9 isoform X1

      UniProtKB/TrEMBL
      F7EUE3
      Conserved Domains (4) summary
      cd04403
      Location:432 → 636
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:227 → 340
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:241 → 339
      PH; PH domain
      cl17036
      Location:27 → 82
      SH3; Src Homology 3 domain superfamily

    5. XM_017594927.3 → XP_017450416.1  rho GTPase-activating protein 9 isoform X5

      Conserved Domains (2) summary
      cd04403
      Location:251 → 455
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:46 → 159
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

    6. XM_063263803.1 → XP_063119873.1  rho GTPase-activating protein 9 isoform X5

    7. XM_039079495.2 → XP_038935423.1  rho GTPase-activating protein 9 isoform X6

      Conserved Domains (2) summary
      cd04403
      Location:199 → 403
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:1 → 107
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

    8. XM_039079492.2 → XP_038935420.1  rho GTPase-activating protein 9 isoform X6

      Conserved Domains (2) summary
      cd04403
      Location:199 → 403
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:1 → 107
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain

    9. XM_063263805.1 → XP_063119875.1  rho GTPase-activating protein 9 isoform X7

    10. XM_063263804.1 → XP_063119874.1  rho GTPase-activating protein 9 isoform X5

    11. XM_017594929.3 → XP_017450418.1  rho GTPase-activating protein 9 isoform X6

      Conserved Domains (2) summary
      cd04403
      Location:199 → 403
      RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
      cd13233
      Location:1 → 107
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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