Panx2 pannexin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Panx2provided by RGD
Official Full Name: pannexin 2provided by RGD
Primary source: RGD:735191
See related: EnsemblRapid:ENSRNOG00000055530 AllianceGenome:RGD:735191
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables gap junction channel activity. Involved in cell-cell signaling. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human PANX2 (pannexin 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 50.3), Kidney (RPKM 21.3) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (122018937..122032009)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (120139259..120153056)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (130042948..130053034)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Panx2 is an important regulator of the insulin secretory capacity and apoptosis in pancreatic beta-cells.
Title: Pannexin-2-deficiency sensitizes pancreatic β-cells to cytokine-induced apoptosis in vitro and impairs glucose tolerance in vivo.
pannexin 2 is expressed in both endothelium and smooth muscle of middle cerebral arteries.
Title: Pannexin protein expression in the rat middle cerebral artery.
Overexpression of pannexins 1 and 2 in pituitary cells enhanced the release of ATP.
Title: Expression and roles of pannexins in ATP release in the pituitary gland.
Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other
Title: Pannexin1 and Pannexin2 channels show quaternary similarities to connexons and different oligomerization numbers from each other.
Results show that pannexins 1, 2, and 3 are abundantly expressed in the mouse and rat cochlea and demonstrate distinct cellular distributions.
Title: Identification and characterization of pannexin expression in the mammalian cochlea.
We noted the expression of Px2 in astrocytes of reactive gliosis in the hippocampus after I/R injury. Px2 mediates the formation of hemichannels for the release of signaling molecules devoted to influence the cellular metabolism .
Title: Expression of pannexin2 protein in healthy and ischemized brain of adult rats.
Panx1 and Panx2 are abundantly expressed in the retina, and may therefore contribute to the electrical and metabolic coupling, or to signaling between retinal neurons
Title: Expression of pannexin family of proteins in the retina.
the different expression patterns of pannexin 1 (Panx1) and pannexin 2 (Panx2) in the brain indicate that pannexins form cell type-specific gap junctions with distinct properties that may subserve different functions.
Title: Pannexins, a family of gap junction proteins expressed in brain.

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General gene information

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Markers

RH139916 (e-PCR)
- UniSTS:222000

RH134180 (e-PCR)
- UniSTS:217462

GDB:182516 (e-PCR)
- UniSTS:155384

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables channel activity	IEA Inferred from Electronic Annotation more info
enables gap junction channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
NOT enables gap junction hemi-channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables structural molecule activity	ISS Inferred from Sequence or Structural Similarity more info
enables wide pore channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell-cell signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic cation transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-1 production	IEA Inferred from Electronic Annotation more info
involved_in response to ischemia	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to ischemia	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in gap junction	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pannexin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199409.2 → NP_955441.2 pannexin-2

See identical proteins and their annotated locations for NP_955441.2

Status: VALIDATED

Source sequence(s)

AJ557016, BC112319, BQ204587

UniProtKB/Swiss-Prot

P60571

UniProtKB/TrEMBL

A6K7I7

Conserved Domains (2) summary

PRK11633
Location:400 → 469

PRK11633; cell division protein DedD; Provisional

cl03000
Location:58 → 150

Innexin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

122018937..122032009

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079619.2 → XP_038935547.1 pannexin-2 isoform X1

UniProtKB/TrEMBL

A6K7I7

Related

ENSRNOP00000069647.3, ENSRNOT00000089707.3

Conserved Domains (1) summary

cl03000
Location:58 → 150

Innexin
XM_039079620.2 → XP_038935548.1 pannexin-2 isoform X2

UniProtKB/TrEMBL

A0A8I6A329, A6K7I7

Related

ENSRNOP00000085314.1, ENSRNOT00000111032.2

Conserved Domains (2) summary

PRK11633
Location:400 → 469

PRK11633; cell division protein DedD; Provisional

cl03000
Location:58 → 150

Innexin
XM_039079622.2 → XP_038935550.1 pannexin-2 isoform X3

UniProtKB/TrEMBL

R9PXY9
XM_039079621.2 → XP_038935549.1 pannexin-2 isoform X3

UniProtKB/TrEMBL

R9PXY9