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    Znf57l zinc finger protein 57 like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100125368, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Znf57lprovided by RGD
    Official Full Name
    zinc finger protein 57 likeprovided by RGD
    Primary source
    RGD:1642422
    See related
    EnsemblRapid:ENSRNOG00000068608 AllianceGenome:RGD:1642422
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including ZNF490 (zinc finger protein 490). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 38.4), Liver (RPKM 34.5) and 9 other tissues See more
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    Genomic context

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    See Znf57l in Genome Data Viewer
    Location:
    7q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (8688422..8712170, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8037649..8060640, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (10893763..10916685, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 433 like Neighboring gene uncharacterized LOC130046242 Neighboring gene ankyrin repeat domain 24 Neighboring gene sirtuin 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156774

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC100125368
    Names
    zinc finger protein 431-like
    zinc finger protein 709-like
    zinc finger protein LOC100125368

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001139487.1 → NP_001132959.1  uncharacterized protein LOC100125368

      See identical proteins and their annotated locations for NP_001132959.1

      Status: VALIDATED

      Source sequence(s)
      BC128765
      UniProtKB/TrEMBL
      A1A5R0
      Related
      ENSRNOP00000058056.3, ENSRNOT00000031481.5
      Conserved Domains (5) summary
      cd07765
      Location:4 → 41
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00349
      Location:4 → 47
      KRAB; krueppel associated box
      COG5048
      Location:104 → 476
      COG5048; FOG: Zn-finger [General function prediction only]
      pfam13465
      Location:428 → 453
      zf-H2C2_2; Zinc-finger double domain
      sd00017
      Location:136 → 156
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      8688422..8712170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262828.1 → XP_063118898.1  uncharacterized protein LOC100125368 isoform X2

    2. XM_008765080.4 → XP_008763302.1  uncharacterized protein LOC100125368 isoform X1

      See identical proteins and their annotated locations for XP_008763302.1

      Conserved Domains (3) summary
      COG5048
      Location:72 → 444
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:104 → 124
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:396 → 421
      zf-H2C2_2; Zinc-finger double domain

    3. XM_006240835.5 → XP_006240897.1  uncharacterized protein LOC100125368 isoform X1

      See identical proteins and their annotated locations for XP_006240897.1

      Conserved Domains (3) summary
      COG5048
      Location:72 → 444
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:104 → 124
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:396 → 421
      zf-H2C2_2; Zinc-finger double domain

    4. XM_063262827.1 → XP_063118897.1  uncharacterized protein LOC100125368 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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