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    Tipin timeless interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363076, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tipinprovided by RGD
    Official Full Name
    timeless interacting proteinprovided by RGD
    Primary source
    RGD:1564084
    See related
    EnsemblRapid:ENSRNOG00000043068 AllianceGenome:RGD:1564084
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    UV98; RGD1564084
    Summary
    The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM and aids in protecting cells against DNA damage and stress. [provided by RefSeq, Feb 2014]
    Expression
    Biased expression in Thymus (RPKM 124.7), Spleen (RPKM 98.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tipin in Genome Data Viewer
    Location:
    8q24
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (73676020..73696620)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (64780813..64801358)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (69753363..69768640)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene small nuclear RNA activating complex, polypeptide 5 Neighboring gene mitogen activated protein kinase kinase 1 Neighboring gene uncharacterized LOC134480193 Neighboring gene transfer RNA serine (anticodon AGA) 48 Neighboring gene small Cajal body-specific RNA 14 Neighboring gene DIS3-like exosome 3'-5' exoribonuclease Neighboring gene multiple EGF-like-domains 11 Neighboring gene uncharacterized LOC134480194

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint. Yoshizawa-Sugata N, et al. J Biol Chem, 2007 Jan 26. PMID 17102137
    2. Tipin, a novel timeless-interacting protein, is developmentally co-expressed with timeless and disrupts its self-association. Gotter AL. J Mol Biol, 2003 Aug 1. PMID 12875843
    3. Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors. Gotter AL, et al. J Mol Biol, 2007 Feb 9. PMID 17141802, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114381

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication checkpoint signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA replication checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell cycle phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell cycle phase transition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in replication fork arrest IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of replication fork protection complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TIMELESS-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025287.2 → NP_001020458.1  TIMELESS-interacting protein

      See identical proteins and their annotated locations for NP_001020458.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q4QR88
      UniProtKB/TrEMBL
      A6J5B9, F1LM96
      Related
      ENSRNOP00000059833.4, ENSRNOT00000066973.5
      Conserved Domains (1) summary
      pfam07962
      Location:63 → 145
      Swi3; Replication Fork Protection Component Swi3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      73676020..73696620
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265765.1 → XP_063121835.1  TIMELESS-interacting protein isoform X4

    2. XM_063265763.1 → XP_063121833.1  TIMELESS-interacting protein isoform X3

    3. XM_039081743.2 → XP_038937671.1  TIMELESS-interacting protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6A0L4, F1LM96
      Related
      ENSRNOP00000100210.1, ENSRNOT00000166332.1
      Conserved Domains (1) summary
      pfam07962
      Location:116 → 198
      Swi3; Replication Fork Protection Component Swi3

    4. XM_063265762.1 → XP_063121832.1  TIMELESS-interacting protein isoform X2

      UniProtKB/TrEMBL
      F1LM96
      Related
      ENSRNOP00000083756.2, ENSRNOT00000112754.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4QR88.1 GenPept UniProtKB/Swiss-Prot:Q4QR88

    Gene LinkOut

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