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    Unc5cl unc-5 family C-terminal like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 301225, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Unc5clprovided by RGD
    Official Full Name
    unc-5 family C-terminal likeprovided by RGD
    Primary source
    RGD:1587368
    See related
    EnsemblRapid:ENSRNOG00000046601 AllianceGenome:RGD:1587368
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable peptidase activity. Predicted to be involved in positive regulation of JNK cascade and positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in membrane. Orthologous to human UNC5CL (unc-5 family C-terminal like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 65.3), Liver (RPKM 17.8) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Unc5cl in Genome Data Viewer
    Location:
    9q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (20025719..20041083, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (12528109..12543382, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (14494080..14510302, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547840 Neighboring gene uncharacterized LOC102548200 Neighboring gene translocator protein 2 Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 2 Neighboring gene O-acyl-ADP-ribose deacylase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade. Heinz LX, et al. Cell Death Differ, 2012 Apr. PMID 22158417, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables netrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in netrin-activated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    UNC5C-like protein
    Names
    unc-5 homolog C-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106882.3 → NP_001100352.2  UNC5C-like protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A096MKD8
      Related
      ENSRNOP00000068477.1, ENSRNOT00000076531.3
      Conserved Domains (3) summary
      pfam00791
      Location:108 → 185
      ZU5; ZU5 domain
      pfam17217
      Location:243 → 346
      UPA; UPA domain
      cl14633
      Location:408 → 488
      DD; Death Domain Superfamily of protein-protein interaction domains

    2. NM_001431992.1 → NP_001418921.1  UNC5C-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A6JIE2

    RNA

    1. NR_197263.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      20025719..20041083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244422.4 → XP_006244484.1  UNC5C-like protein isoform X1

      See identical proteins and their annotated locations for XP_006244484.1

      UniProtKB/TrEMBL
      A0A096MKD8
      Conserved Domains (3) summary
      pfam00791
      Location:108 → 185
      ZU5; ZU5 domain
      pfam17217
      Location:243 → 346
      UPA; UPA domain
      cl14633
      Location:408 → 488
      DD; Death Domain Superfamily of protein-protein interaction domains

    2. XM_063266843.1 → XP_063122913.1  UNC5C-like protein isoform X1

      UniProtKB/TrEMBL
      A0A096MKD8

    3. XM_006244423.5 → XP_006244485.1  UNC5C-like protein isoform X2

      Conserved Domains (2) summary
      pfam00791
      Location:103 → 185
      ZU5; ZU5 domain
      cl14633
      Location:408 → 445
      DD; Death Domain Superfamily of protein-protein interaction domains

    4. XM_063266842.1 → XP_063122912.1  UNC5C-like protein isoform X1

    5. XM_039083172.1 → XP_038939100.1  UNC5C-like protein isoform X3

      Conserved Domains (2) summary
      pfam17217
      Location:4 → 105
      UPA; UPA domain
      cl14633
      Location:158 → 238
      DD; Death Domain Superfamily of protein-protein interaction domains

    RNA

    1. XR_005488861.2 RNA Sequence

    2. XR_005488862.2 RNA Sequence

    3. XR_005488863.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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