Kif4a kinesin family member 4A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kif4aprovided by RGD
Official Full Name: kinesin family member 4Aprovided by RGD
Primary source: RGD:620526
See related: EnsemblRapid:ENSRNOG00000038035 AllianceGenome:RGD:620526
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kif4
Summary: Predicted to enable microtubule motor activity. Predicted to be involved in mitotic cytokinesis and mitotic spindle midzone assembly. Predicted to be located in midbody and nucleoplasm. Predicted to be part of microtubule associated complex. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 100. Orthologous to several human genes including KIF4A (kinesin family member 4A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 113.4), Spleen (RPKM 81.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq22

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (69761803..69864335)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (65721746..65824277)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (70461700..70561084)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of KIF4A expression with shRNA reduced the level of integrin beta1 in axons of developing neurons.
Title: Kinesin KIF4A transports integrin β1 in developing axons of cortical neurons.
KIF4 is involved in the anterograde trafficking of ribosomal constituents to axons
Title: KIF4 mediates anterograde translocation and positioning of ribosomal constituents to axons.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle midzone assembly	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in spindle elongation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of microtubule associated complex	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: chromosome-associated kinesin KIF4A

Names: kinesin family member 4; kinesin heavy chain member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001400930.1 → NP_001387859.1 chromosome-associated kinesin KIF4A

Status: VALIDATED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A6IQ86, E9PSJ3

Related

ENSRNOP00000073033.1, ENSRNOT00000078233.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

69761803..69864335

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006257114.4 → XP_006257176.1 chromosome-associated kinesin KIF4A isoform X1

See identical proteins and their annotated locations for XP_006257176.1

UniProtKB/TrEMBL

A6IQ86, E9PSJ3

Conserved Domains (6) summary

smart00129
Location:9 → 344

KISc; Kinesin motor, catalytic domain. ATPase

COG4985
Location:494 → 638

COG4985; ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]

cd01372
Location:8 → 338

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

pfam05033
Location:1070 → 1120

Pre-SET; Pre-SET motif

pfam07111
Location:390 → 1057

HCR; Alpha helical coiled-coil rod protein (HCR)

cl00656
Location:681 → 744

Cas1_I-II-III; CRISPR/Cas system-associated protein Cas1