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    Magea4 MAGE family member A4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689858, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Magea4provided by RGD
    Official Full Name
    MAGE family member A4provided by RGD
    Primary source
    RGD:1587522
    See related
    EnsemblRapid:ENSRNOG00000075783 AllianceGenome:RGD:1587522
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including MAGEA10 (MAGE family member A10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 8.0) See more
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    Genomic context

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    See Magea4 in Genome Data Viewer
    Location:
    Xq37
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (155073718..155080164)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (150035874..150038095)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (152192043..152197596)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene tubulin, alpha 1B, pseudogene 11 Neighboring gene cyclic nucleotide gated channel subunit alpha 2 Neighboring gene microRNA 224 Neighboring gene gamma-aminobutyric acid type A receptor subunit epsilon Neighboring gene MAGE family member A10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MAGE family member A4
    Names
    melanoma antigen, family A, 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109550.2 → NP_001103020.1  MAGE family member A4

      See identical proteins and their annotated locations for NP_001103020.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6GC30, A6KSX3
      Related
      ENSRNOP00000092782.2, ENSRNOT00000112875.2
      Conserved Domains (2) summary
      pfam01454
      Location:102 → 270
      MAGE; MAGE family
      pfam12440
      Location:13 → 82
      MAGE_N; Melanoma associated antigen family N terminal

    2. NM_001428949.1 → NP_001415878.1  MAGE family member A4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A0A8I6GC30, A6KSX3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      155073718..155080164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063280311.1 → XP_063136381.1  MAGE family member A4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GC30, A6KSX3

    2. XM_063280310.1 → XP_063136380.1  MAGE family member A4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GC30, A6KSX3

    3. XM_039100081.2 → XP_038956009.1  MAGE family member A4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GC30, A6KSX3
      Conserved Domains (2) summary
      pfam01454
      Location:102 → 270
      MAGE; MAGE family
      pfam12440
      Location:13 → 82
      MAGE_N; Melanoma associated antigen family N terminal

    4. XM_063280309.1 → XP_063136379.1  MAGE family member A4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GC30, A6KSX3
    Nucleotide Protein Strain
    Heading Accession and Version

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