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    Fut10 fucosyltransferase 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497619, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fut10provided by RGD
    Official Full Name
    fucosyltransferase 10provided by RGD
    Primary source
    RGD:1359164
    See related
    EnsemblRapid:ENSRNOG00000050857 AllianceGenome:RGD:1359164
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    fut10A
    Summary
    Predicted to enable alpha-(1->3)-fucosyltransferase activity. Predicted to be involved in N-glycan fucosylation; neuronal stem cell division; and oligosaccharide biosynthetic process. Predicted to act upstream of or within cerebral cortex radially oriented cell migration; neuroblast migration; and neuronal stem cell population maintenance. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and nucleoplasm. Orthologous to human FUT10 (fucosyltransferase 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 41.7), Muscle (RPKM 41.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fut10 in Genome Data Viewer
    Location:
    16q12.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (67571828..67661814, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (60868761..60958762, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (64623246..64716248, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene heat shock protein 90 alpha family class B member 1, pseudogene 4 Neighboring gene small nucleolar RNA, C/D box 13 Neighboring gene MAK16 homolog Neighboring gene TELO2 interacting protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Lewis X-related α1,3-fucosyltransferase, Fut10, is required for the maintenance of stem cell populations. Kumar A, et al. J Biol Chem, 2013 Oct 4. PMID 23986452, Free PMC Article
    2. Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11). Mollicone R, et al. J Biol Chem, 2009 Feb 13. PMID 19088067
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-(1->3)-fucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-(1->3)-fucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-(1->3)-fucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fucosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan fucosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in N-glycan fucosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-glycan fucosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cerebral cortex radially oriented cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cerebral cortex radially oriented cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuroblast migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neuroblast migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuronal stem cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuronal stem cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuronal stem cell division ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuronal stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neuronal stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oligosaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    alpha-(1,3)-fucosyltransferase 10
    Names
    alpha3-fucosyltransferase
    fuc-TX
    fucT-X
    fucosyltransferase X
    galactoside 3-L-fucosyltransferase 10
    NP_001012360.2
    NP_001398690.1
    XP_017455693.1
    XP_017455694.1
    XP_017455695.1
    XP_038950678.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012360.2 → NP_001012360.2  alpha-(1,3)-fucosyltransferase 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q5F2L1, Q5F2N5
      UniProtKB/TrEMBL
      A6IVV7
      Related
      ENSRNOP00000105756.1, ENSRNOT00000122546.1

    2. NM_001411761.1 → NP_001398690.1  alpha-(1,3)-fucosyltransferase 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q5F2L1, Q5F2N5
      UniProtKB/TrEMBL
      M0R8J2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      67571828..67661814 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600205.3 → XP_017455694.1  alpha-(1,3)-fucosyltransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      Q5F2L1, Q5F2N5
      UniProtKB/TrEMBL
      M0R8J2
      Conserved Domains (2) summary
      pfam00852
      Location:219 → 354
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:83 → 181
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    2. XM_017600204.3 → XP_017455693.1  alpha-(1,3)-fucosyltransferase 10 isoform X1

      UniProtKB/Swiss-Prot
      Q5F2L1, Q5F2N5
      UniProtKB/TrEMBL
      M0R8J2
      Conserved Domains (2) summary
      pfam00852
      Location:219 → 354
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:83 → 181
      Glyco_tran_10_N; Fucosyltransferase, N-terminal

    3. XM_017600206.3 → XP_017455695.1  alpha-(1,3)-fucosyltransferase 10 isoform X2

      Related
      ENSRNOP00000110497.1, ENSRNOT00000171736.1

    4. XM_039094750.2 → XP_038950678.1  alpha-(1,3)-fucosyltransferase 10 isoform X3

      Conserved Domains (2) summary
      pfam00852
      Location:102 → 237
      Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
      pfam17039
      Location:4 → 64
      Glyco_tran_10_N; Fucosyltransferase, N-terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5F2L1.1 GenPept UniProtKB/Swiss-Prot:Q5F2L1

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