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    Stx5 syntaxin 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 65134, updated on 4-Jan-2025

    Summary

    Official Symbol
    Stx5provided by RGD
    Official Full Name
    syntaxin 5provided by RGD
    Primary source
    RGD:68426
    See related
    EnsemblRapid:ENSRNOG00000018847 AllianceGenome:RGD:68426
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Stx5a
    Summary
    Predicted to enable SNAP receptor activity and SNARE binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and vesicle fusion with Golgi apparatus. Located in Golgi membrane. Part of SNARE complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human STX5 (syntaxin 5). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Lung (RPKM 171.2), Thymus (RPKM 164.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Stx5 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (215066532..215082685)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (205637401..205653563)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (224939497..224955658)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene WD repeat domain 74 Neighboring gene testis expressed 54 Neighboring gene nuclear RNA export factor 1 Neighboring gene transmembrane protein 223

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC156622

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SNAP receptor activity  
    enables SNAP receptor activity  
    enables SNAP receptor activity  
    enables SNARE binding  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in Golgi disassembly  
    involved_in early endosome to Golgi transport  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport PubMed 
    involved_in intracellular protein transport  
    involved_in intracellular protein transport  
    involved_in membrane fusion  
    involved_in positive regulation of protein catabolic process  
    involved_in regulation of Golgi organization  
    involved_in retrograde transport, endosome to Golgi  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum  
    involved_in vesicle docking  
    involved_in vesicle fusion  
    involved_in vesicle fusion with Golgi apparatus PubMed 
    involved_in vesicle-mediated transport  
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    is_active_in Golgi membrane  
    located_in Golgi membrane PubMed 
    part_of SNARE complex  
    part_of SNARE complex PubMed 
    located_in cytosol  
    is_active_in endomembrane system  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane  
    located_in membrane  
    located_in vesicle  

    General protein information

    Preferred Names
    syntaxin-5
    Names
    syntaxin 5a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031704.2NP_113892.2  syntaxin-5

      Status: VALIDATED

      Source sequence(s)
      BC127489
      UniProtKB/Swiss-Prot
      A0JPL4, O55200, Q08851
      UniProtKB/TrEMBL
      A0A8L2QDM8, A6HZT3
      Conserved Domains (3) summary
      COG5325
      Location:80324
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15844
      Location:266338
      SNARE_syntaxin5; SNARE motif of syntaxin 5
      pfam11416
      Location:5273
      Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      215066532..215082685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230997.4XP_006231059.1  syntaxin-5 isoform X1

      UniProtKB/Swiss-Prot
      A0JPL4, O55200, Q08851
      UniProtKB/TrEMBL
      A0A8L2QDM8, A6HZT3
      Related
      ENSRNOP00000025664.6, ENSRNOT00000025664.7
      Conserved Domains (3) summary
      COG5325
      Location:80324
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15844
      Location:266338
      SNARE_syntaxin5; SNARE motif of syntaxin 5
      pfam11416
      Location:5273
      Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain
    2. XM_039089892.2XP_038945820.1  syntaxin-5 isoform X1

      UniProtKB/Swiss-Prot
      A0JPL4, O55200, Q08851
      UniProtKB/TrEMBL
      A0A8L2QDM8, A6HZT3
      Conserved Domains (3) summary
      COG5325
      Location:80324
      COG5325; t-SNARE complex subunit, syntaxin [Intracellular trafficking and secretion]
      cd15844
      Location:266338
      SNARE_syntaxin5; SNARE motif of syntaxin 5
      pfam11416
      Location:5273
      Syntaxin-5_N; Syntaxin-5 N-terminal, Sly1p-binding domain
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