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    Sqstm1 sequestosome 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 113894, updated on 4-Jan-2025

    Summary

    Official Symbol
    Sqstm1provided by RGD
    Official Full Name
    sequestosome 1provided by RGD
    Primary source
    RGD:69287
    See related
    EnsemblRapid:ENSRNOG00000003147 AllianceGenome:RGD:69287
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Osi; ZIP; ZIP3
    Summary
    Enables identical protein binding activity and protein kinase C binding activity. Involved in positive regulation of protein phosphorylation and response to ischemia. Located in Lewy body. Is active in glutamatergic synapse. Biomarker of acute myocardial infarction; glaucoma; and hypertension. Human ortholog(s) of this gene implicated in Paget's disease of bone; Paget's disease of bone 3; distal myopathy with rimmed vacuoles; frontotemporal dementia and/or amyotrophic lateral sclerosis 3; and neurodegeneration with ataxia, dystonia, and gaze palsy, childhood-onset. Orthologous to human SQSTM1 (sequestosome 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Liver (RPKM 1406.7), Muscle (RPKM 1246.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Sqstm1 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (35026598..35037750, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (34525517..34536670, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (35704728..35716316, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 9B Neighboring gene uncharacterized LOC120095090 Neighboring gene MRN complex interacting protein Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B Neighboring gene uncharacterized LOC134480781 Neighboring gene leukotriene C4 synthase Neighboring gene mastermind-like transcriptional coactivator 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 30
    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding  
    enables K63-linked polyubiquitin modification-dependent protein binding  
    enables K63-linked polyubiquitin modification-dependent protein binding  
    enables SH2 domain binding  
    enables SH2 domain binding  
    enables enzyme binding  
    enables identical protein binding  
    enables identical protein binding  
    enables ionotropic glutamate receptor binding  
    enables molecular condensate scaffold activity  
    enables molecular sequestering activity  
    enables protein binding  
    enables protein kinase C binding  
    enables protein kinase C binding  
    enables protein kinase C binding  
    enables protein kinase C binding  
    enables protein kinase binding  
    enables protein sequestering activity  
    enables protein sequestering activity  
    enables protein-containing complex binding PubMed 
    enables protein-macromolecule adaptor activity  
    enables protein-macromolecule adaptor activity  
    enables signaling adaptor activity  
    enables signaling receptor activity  
    enables ubiquitin binding  
    enables ubiquitin binding  
    enables ubiquitin protein ligase binding  
    enables ubiquitin-modified protein reader activity  
    enables ubiquitin-modified protein reader activity  
    enables zinc ion binding  
    Items 1 - 25 of 30
    Items 1 - 25 of 46
    Process Evidence Code Pubs
    involved_in aggrephagy  
    involved_in aggrephagy  
    involved_in aggrephagy  
    involved_in apoptotic process  
    involved_in autophagy  
    involved_in autophagy  
    involved_in brown fat cell proliferation  
    involved_in cell differentiation  
    involved_in cellular response to stress  
    involved_in endosome organization  
    involved_in endosome organization  
    involved_in endosome organization  
    involved_in energy homeostasis  
    involved_in immune system process  
    involved_in macroautophagy  
    involved_in macroautophagy  
    involved_in membraneless organelle assembly  
    involved_in mitophagy  
    involved_in mitophagy  
    involved_in negative regulation of ferroptosis  
    involved_in negative regulation of ferroptosis  
    involved_in negative regulation of protein ubiquitination  
    involved_in negative regulation of protein ubiquitination  
    involved_in negative regulation of toll-like receptor 4 signaling pathway  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in pexophagy  
    involved_in pexophagy  
    involved_in positive regulation of autophagy  
    involved_in positive regulation of long-term synaptic potentiation  
    involved_in positive regulation of protein localization to plasma membrane  
    involved_in positive regulation of protein phosphorylation PubMed 
    involved_in protein catabolic process  
    involved_in protein catabolic process  
    involved_in protein import into nucleus  
    involved_in protein localization to perinuclear region of cytoplasm  
    involved_in protein localization to perinuclear region of cytoplasm  
    involved_in protein phosphorylation  
    involved_in protein targeting to vacuole involved in autophagy  
    involved_in protein targeting to vacuole involved in autophagy  
    involved_in regulation of canonical NF-kappaB signal transduction  
    involved_in regulation of canonical NF-kappaB signal transduction  
    involved_in regulation of protein complex stability  
    involved_in response to ischemia PubMed 
    involved_in response to mitochondrial depolarisation  
    involved_in temperature homeostasis  
    acts_upstream_of transcription by RNA polymerase II  
    Items 1 - 25 of 46
    Items 1 - 20 of 29
    Component Evidence Code Pubs
    located_in Lewy body PubMed 
    located_in P-body  
    located_in P-body  
    located_in PML body  
    is_active_in aggresome  
    located_in aggresome  
    is_active_in amphisome  
    located_in amphisome  
    located_in autolysosome  
    located_in autophagosome  
    is_active_in autophagosome  
    located_in autophagosome  
    located_in autophagosome  
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    located_in endoplasmic reticulum  
    is_active_in glutamatergic synapse PubMed 
    located_in inclusion body  
    located_in intracellular membrane-bounded organelle  
    is_active_in intracellular membraneless organelle  
    is_active_in intracellular membraneless organelle  
    located_in late endosome  
    located_in mitochondrion  
    located_in nucleus  
    located_in phagophore assembly site  
    located_in sarcomere  
    located_in sperm midpiece  
    is_active_in synapse PubMed 
    Items 1 - 20 of 29

    General protein information

    Preferred Names
    sequestosome-1
    Names
    PKC-zeta-interacting protein
    oxidative stress induced
    protein kinase C-zeta-interacting protein
    ubiquitin-binding protein p62

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393884.1NP_001380813.1  sequestosome-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HE00
      Related
      ENSRNOP00000004308.8, ENSRNOT00000004308.8
      Conserved Domains (3) summary
      cd06402
      Location:4100
      PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...
      cd02340
      Location:123163
      ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
      pfam16577
      Location:351412
      UBA_5; UBA domain
    2. NM_001393885.1NP_001380814.1  sequestosome-1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HE02
      Conserved Domains (3) summary
      cd06402
      Location:4100
      PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...
      cd02340
      Location:123163
      ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
      cl21463
      Location:350401
      UBA_like_SF; UBA domain-like superfamily
    3. NM_001393886.1NP_001380815.1  sequestosome-1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HE02
      Conserved Domains (3) summary
      cd06402
      Location:4100
      PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...
      cd02340
      Location:123163
      ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
      cl21463
      Location:323374
      UBA_like_SF; UBA domain-like superfamily
    4. NM_175843.5NP_787037.2  sequestosome-1 isoform 1

      See identical proteins and their annotated locations for NP_787037.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      O08623, Q8CH59
      UniProtKB/TrEMBL
      A6HE00
      Related
      ENSRNOP00000056021.4, ENSRNOT00000059255.7
      Conserved Domains (3) summary
      cd06402
      Location:4100
      PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...
      cd02340
      Location:123163
      ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
      pfam16577
      Location:378439
      UBA_5; UBA domain
    5. NM_181550.2NP_853528.2  sequestosome-1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and its transcription extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HE03
      Conserved Domains (2) summary
      cd06402
      Location:4100
      PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...
      cd02340
      Location:123163
      ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      35026598..35037750 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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