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    Erap1 endoplasmic reticulum aminopeptidase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 80897, updated on 9-Dec-2024

    Summary

    Official Symbol
    Erap1provided by RGD
    Official Full Name
    endoplasmic reticulum aminopeptidase 1provided by RGD
    Primary source
    RGD:708542
    See related
    EnsemblRapid:ENSRNOG00000009997 AllianceGenome:RGD:708542
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Arts1; Appils
    Summary
    Enables aminopeptidase activity; tumor necrosis factor receptor binding activity; and zinc ion binding activity. Involved in protein catabolic process. Located in endoplasmic reticulum lumen. Human ortholog(s) of this gene implicated in cervix carcinoma. Orthologous to human ERAP1 (endoplasmic reticulum aminopeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 180.9), Lung (RPKM 177.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Erap1 in Genome Data Viewer
    Location:
    2q11
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (5666337..5705256)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (3931817..3970735)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (1410877..1449734)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ATP synthase peripheral stalk subunit F6, pseudogene 4 Neighboring gene uncharacterized LOC102548635 Neighboring gene calpastatin Neighboring gene uncharacterized LOC134485561 Neighboring gene RNA, U6 small nuclear 1303

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC112613

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aminopeptidase activity  
    enables aminopeptidase activity PubMed 
    enables aminopeptidase activity  
    enables aminopeptidase activity  
    enables endopeptidase activity  
    enables interleukin-6 receptor binding  
    enables interleukin-6 receptor binding  
    enables metalloaminopeptidase activity  
    enables metalloexopeptidase activity  
    enables metalloexopeptidase activity  
    enables metallopeptidase activity  
    enables peptidase activity  
    enables peptide binding  
    enables tumor necrosis factor receptor binding PubMed 
    enables zinc ion binding  
    enables zinc ion binding  
    enables zinc ion binding PubMed 
    Process Evidence Code Pubs
    involved_in adaptive immune response  
    involved_in antigen processing and presentation PubMed 
    involved_in membrane protein ectodomain proteolysis  
    involved_in membrane protein ectodomain proteolysis  
    involved_in peptide catabolic process  
    involved_in positive regulation of angiogenesis  
    acts_upstream_of_or_within positive regulation of angiogenesis  
    involved_in protein catabolic process PubMed 
    involved_in proteolysis  
    involved_in proteolysis  
    acts_upstream_of_or_within proteolysis  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in endoplasmic reticulum lumen PubMed 
    located_in endoplasmic reticulum membrane  
    located_in extracellular region  
    located_in extracellular region  
    is_active_in extracellular space  
    is_active_in membrane  
    located_in membrane  

    General protein information

    Preferred Names
    endoplasmic reticulum aminopeptidase 1
    Names
    A-LAP
    ARTS-1
    ER-aminopeptidase 1
    PILS-AP
    adipocyte-derived leucine aminopeptidase
    aminopeptidase PILS
    leucyl-specific aminopeptidase PILS
    puromycin-insensitive leucyl-specific aminopeptidase
    type 1 tumor necrosis factor receptor shedding aminopeptidase regulator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399166.1NP_001386095.1  endoplasmic reticulum aminopeptidase 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q9JJ22, Q9JJ23
      UniProtKB/TrEMBL
      Q4KMA8
      Related
      ENSRNOP00000104412.1, ENSRNOT00000133925.1
      Conserved Domains (2) summary
      cd09601
      Location:50515
      M1_APN-Q_like; Peptidase M1 aminopeptidase N catalytic domain family which includes aminopeptidase N (APN), aminopeptidase Q (APQ), tricorn interacting factor F3, and endoplasmic reticulum aminopeptidase 1 (ERAP1)
      pfam11838
      Location:586905
      ERAP1_C; ERAP1-like C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      5666337..5705256
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760601.4XP_008758823.1  endoplasmic reticulum aminopeptidase 1 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K2Y3, A6I4D9
      Conserved Domains (3) summary
      cd09601
      Location:50544
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:42454
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:611919
      ERAP1_C; ERAP1-like C-terminal domain
    2. XM_006231701.5XP_006231763.1  endoplasmic reticulum aminopeptidase 1 isoform X1

      See identical proteins and their annotated locations for XP_006231763.1

      UniProtKB/Swiss-Prot
      Q9JJ22, Q9JJ23
      UniProtKB/TrEMBL
      F7F4R3
      Related
      ENSRNOP00000013625.5, ENSRNOT00000013625.7
      Conserved Domains (3) summary
      cd09601
      Location:50544
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:42454
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:611927
      ERAP1_C; ERAP1-like C-terminal domain
    3. XM_063282613.1XP_063138683.1  endoplasmic reticulum aminopeptidase 1 isoform X4

      UniProtKB/TrEMBL
      A0A0G2K2Y3, A0A8I5ZYK5, A6I4D9
      Related
      ENSRNOP00000072424.1, ENSRNOT00000080222.3
    4. XM_063282612.1XP_063138682.1  endoplasmic reticulum aminopeptidase 1 isoform X3

      UniProtKB/Swiss-Prot
      Q9JJ22, Q9JJ23
      UniProtKB/TrEMBL
      Q4KMA8
    5. XM_006231700.3XP_006231762.1  endoplasmic reticulum aminopeptidase 1 isoform X1

      See identical proteins and their annotated locations for XP_006231762.1

      UniProtKB/Swiss-Prot
      Q9JJ22, Q9JJ23
      UniProtKB/TrEMBL
      F7F4R3
      Conserved Domains (3) summary
      cd09601
      Location:50544
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:42454
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:611927
      ERAP1_C; ERAP1-like C-terminal domain
    6. XM_063282614.1XP_063138684.1  endoplasmic reticulum aminopeptidase 1 isoform X5

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