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    Dspp dentin sialophosphoprotein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25254, updated on 4-Jan-2025

    Summary

    Official Symbol
    Dsppprovided by RGD
    Official Full Name
    dentin sialophosphoproteinprovided by RGD
    Primary source
    RGD:2525
    See related
    EnsemblRapid:ENSRNOG00000002168 AllianceGenome:RGD:2525
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dsp; RDSP2
    Summary
    Enables collagen binding activity. Involved in several processes, including cellular response to dexamethasone stimulus; mandibular condyle articular cartilage development; and odontoblast differentiation. Acts upstream of or within positive regulation of calcium ion import. Located in collagen-containing extracellular matrix; nucleus; and plasma membrane. Biomarker of osteoporosis. Human ortholog(s) of this gene implicated in dentinogenesis imperfecta. Orthologous to human DSPP (dentin sialophosphoprotein). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See Dspp in Genome Data Viewer
    Location:
    14p22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (5870232..5876339, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (5565562..5571669, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (6926972..6933079, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096547 Neighboring gene dentin matrix acidic phosphoprotein 1 Neighboring gene uncharacterized LOC108352697 Neighboring gene SPARC like 1 Neighboring gene secretory calcium-binding phosphoprotein proline-glutamine rich 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables collagen binding  
    enables collagen binding PubMed 
    enables protein binding PubMed 
    Items 1 - 25 of 38
    Process Evidence Code Pubs
    acts_upstream_of_or_within S-shaped body morphogenesis  
    acts_upstream_of_or_within ameloblast differentiation  
    acts_upstream_of_or_within amelogenesis  
    involved_in biomineral tissue development PubMed 
    acts_upstream_of_or_within branching involved in ureteric bud morphogenesis  
    involved_in cartilage development PubMed 
    involved_in cell differentiation PubMed 
    acts_upstream_of_or_within cellular response to cell-matrix adhesion  
    involved_in cellular response to dexamethasone stimulus PubMed 
    involved_in cellular response to hormone stimulus PubMed 
    acts_upstream_of_or_within connective tissue development  
    involved_in dentinogenesis  
    involved_in dentinogenesis PubMed 
    acts_upstream_of_or_within dentinogenesis  
    acts_upstream_of_or_within endochondral bone morphogenesis  
    acts_upstream_of_or_within gene expression involved in extracellular matrix organization  
    involved_in hair follicle maturation PubMed 
    acts_upstream_of_or_within lung morphogenesis  
    involved_in mandibular condyle articular cartilage development PubMed 
    acts_upstream_of_or_within mandibular condyle articular cartilage development  
    acts_upstream_of_or_within mesenchymal to epithelial transition  
    acts_upstream_of_or_within negative regulation of bone development  
    acts_upstream_of_or_within negative regulation of chondrocyte proliferation  
    acts_upstream_of_or_within negative regulation of growth plate cartilage chondrocyte proliferation  
    acts_upstream_of_or_within negative regulation of mesenchymal cell apoptotic process  
    involved_in odontoblast differentiation  
    involved_in odontoblast differentiation PubMed 
    acts_upstream_of_or_within odontoblast differentiation  
    acts_upstream_of_or_within odontogenesis  
    involved_in odontogenesis of dentin-containing tooth PubMed 
    acts_upstream_of_or_within positive regulation of calcium ion import PubMed 
    acts_upstream_of_or_within positive regulation of chondrocyte proliferation  
    acts_upstream_of_or_within positive regulation of enamel mineralization  
    involved_in regulation of odontoblast differentiation PubMed 
    involved_in response to carbohydrate PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to mechanical stimulus PubMed 
    involved_in response to transforming growth factor beta PubMed 
    Items 1 - 25 of 38
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in extracellular matrix  
    located_in extracellular space  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    dentin sialophosphoprotein
    Names
    Dentin sialoprotein
    Dentine sialoprotein
    dentin sailophosphoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012790.3NP_036922.3  dentin sialophosphoprotein precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      E9PTW3
      Related
      ENSRNOP00000002946.5, ENSRNOT00000002946.9
      Conserved Domains (1) summary
      NF033849
      Location:199469
      ser_rich_anae_1; serine-rich protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      5870232..5876339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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