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    Comt catechol-O-methyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24267, updated on 4-Jan-2025

    Summary

    Official Symbol
    Comtprovided by RGD
    Official Full Name
    catechol-O-methyltransferaseprovided by RGD
    Primary source
    RGD:2379
    See related
    EnsemblRapid:ENSRNOG00000001889 AllianceGenome:RGD:2379
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables catechol O-methyltransferase activity. Involved in several processes, including learning or memory; negative regulation of dopamine metabolic process; and positive regulation of homocysteine metabolic process. Located in several cellular components, including cell body; dendritic spine; and postsynaptic membrane. Is active in glutamatergic synapse and postsynapse. Used to study Parkinsonism and hypertension. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease of skin and connective tissue (multiple); cognitive disorder (multiple); drug dependence (multiple); reproductive organ cancer (multiple); and withdrawal disorder (multiple). Orthologous to human COMT (catechol-O-methyltransferase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Liver (RPKM 2550.1), Kidney (RPKM 1227.4) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Comt in Genome Data Viewer
    Location:
    11q23
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (96072371..96091956)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (82568052..82587642)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (86715981..86735630)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene T-box transcription factor 1 Neighboring gene G protein subunit beta 1 like Neighboring gene uncharacterized LOC120095703 Neighboring gene thioredoxin reductase 2 Neighboring gene ARVCF, delta catenin family member Neighboring gene small Cajal body-specific RNA 14 like 2 Neighboring gene transport and golgi organization 2 homolog Neighboring gene microRNA 185

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 78
    Process Evidence Code Pubs
    involved_in S-adenosylhomocysteine metabolic process PubMed 
    involved_in S-adenosylmethionine metabolic process PubMed 
    acts_upstream_of_or_within artery development  
    acts_upstream_of_or_within behavioral fear response  
    involved_in catecholamine catabolic process  
    involved_in catecholamine catabolic process  
    involved_in catecholamine catabolic process  
    involved_in catecholamine catabolic process  
    acts_upstream_of_or_within catecholamine metabolic process  
    acts_upstream_of_or_within cellular response to cocaine  
    acts_upstream_of_or_within cellular response to phosphate starvation  
    acts_upstream_of_or_within cerebellar cortex morphogenesis  
    acts_upstream_of_or_within cholesterol efflux  
    acts_upstream_of_or_within cognition  
    acts_upstream_of_or_within detection of temperature stimulus involved in sensory perception of pain  
    involved_in developmental process  
    involved_in developmental process  
    acts_upstream_of_or_within dopamine catabolic process  
    involved_in dopamine metabolic process  
    involved_in dopamine metabolic process  
    acts_upstream_of_or_within dopamine metabolic process  
    acts_upstream_of_or_within dopamine secretion  
    involved_in estrogen metabolic process PubMed 
    acts_upstream_of_or_within exploration behavior  
    acts_upstream_of_or_within fear response  
    involved_in female pregnancy PubMed 
    acts_upstream_of_or_within gene expression  
    acts_upstream_of_or_within glomerulus development  
    acts_upstream_of_or_within glycogen metabolic process  
    acts_upstream_of_or_within habituation  
    acts_upstream_of_or_within kidney development  
    involved_in learning PubMed 
    acts_upstream_of_or_within learning  
    acts_upstream_of_or_within learning or memory  
    acts_upstream_of_or_within mastication  
    acts_upstream_of_or_within memory  
    involved_in methylation  
    involved_in methylation  
    involved_in methylation  
    acts_upstream_of_or_within multicellular organism growth  
    acts_upstream_of_or_within multicellular organismal response to stress  
    involved_in negative regulation of dopamine metabolic process PubMed 
    involved_in negative regulation of smooth muscle cell proliferation PubMed 
    acts_upstream_of_or_within norepinephrine metabolic process  
    acts_upstream_of_or_within norepinephrine secretion  
    involved_in positive regulation of homocysteine metabolic process PubMed 
    involved_in positive regulation of lactation  
    acts_upstream_of_or_within prostaglandin metabolic process  
    acts_upstream_of_or_within protein methylation  
    acts_upstream_of_or_within protein phosphorylation  
    acts_upstream_of_or_within regulation of blood pressure  
    acts_upstream_of_or_within renal albumin absorption  
    acts_upstream_of_or_within renal filtration  
    acts_upstream_of_or_within renal sodium excretion  
    acts_upstream_of_or_within renin secretion into blood stream  
    acts_upstream_of_or_within response to amphetamine  
    acts_upstream_of_or_within response to angiotensin  
    acts_upstream_of_or_within response to corticosterone  
    acts_upstream_of_or_within response to cytokine  
    acts_upstream_of_or_within response to dopamine  
    involved_in response to estrogen PubMed 
    acts_upstream_of_or_within response to food  
    acts_upstream_of_or_within response to hypoxia  
    involved_in response to lipopolysaccharide PubMed 
    involved_in response to organic cyclic compound PubMed 
    acts_upstream_of_or_within response to oxidative stress  
    involved_in response to pain PubMed 
    acts_upstream_of_or_within response to salt  
    acts_upstream_of_or_within response to stress  
    acts_upstream_of_or_within response to temperature stimulus  
    acts_upstream_of_or_within response to toxic substance  
    acts_upstream_of_or_within response to wounding  
    involved_in response to xenobiotic stimulus PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus  
    involved_in short-term memory PubMed 
    acts_upstream_of_or_within startle response  
    acts_upstream_of_or_within synaptic transmission, dopaminergic  
    acts_upstream_of_or_within visual learning  
    Items 1 - 25 of 78
    Component Evidence Code Pubs
    is_active_in axon  
    located_in axon PubMed 
    located_in cell body PubMed 
    located_in cell body  
    is_active_in cytosol  
    located_in cytosol  
    is_active_in dendrite  
    located_in dendrite PubMed 
    located_in dendritic spine PubMed 
    located_in extracellular space  
    located_in glial cell projection  
    is_active_in glutamatergic synapse PubMed 
    located_in intracellular membrane-bounded organelle  
    located_in intracellular membrane-bounded organelle  
    is_active_in membrane  
    located_in plasma membrane  
    is_active_in postsynapse PubMed 
    located_in postsynaptic membrane PubMed 
    is_active_in vesicle  

    General protein information

    Preferred Names
    catechol O-methyltransferase
    Names
    catecholamine-O-methyltransferase
    NP_036663.1
    XP_006248665.1
    XP_063126344.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012531.2NP_036663.1  catechol O-methyltransferase

      See identical proteins and their annotated locations for NP_036663.1

      Status: VALIDATED

      Source sequence(s)
      BC081850, CK478774
      UniProtKB/Swiss-Prot
      P22734
      UniProtKB/TrEMBL
      A0A8I6AHB1, F2W8B0, F2W8B1
      Related
      ENSRNOP00000092582.1, ENSRNOT00000104392.2
      Conserved Domains (1) summary
      COG4122
      Location:44238
      YrrM; Predicted O-methyltransferase YrrM [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      96072371..96091956
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270274.1XP_063126344.1  catechol O-methyltransferase isoform X2

      UniProtKB/Swiss-Prot
      P22734
      UniProtKB/TrEMBL
      A0A8I6AHB1, F2W8B0, F2W8B1
      Related
      ENSRNOP00000043148.5, ENSRNOT00000050269.7
    2. XM_006248603.5XP_006248665.1  catechol O-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A0A8I6A1I0, A0A8I6AHB1
      Related
      ENSRNOP00000086073.1, ENSRNOT00000119057.2
      Conserved Domains (1) summary
      cl17173
      Location:61228
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
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