Slc7a10 solute carrier family 7 member 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc7a10provided by RGD
Official Full Name: solute carrier family 7 member 10provided by RGD
Primary source: RGD:621672
See related: EnsemblRapid:ENSRNOG00000010938 AllianceGenome:RGD:621672
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Asc-1
Summary: Predicted to enable L-amino acid transmembrane transporter activity and neutral L-amino acid transmembrane transporter activity. Predicted to be involved in negative regulation of brown fat cell differentiation; neutral amino acid transport; and positive regulation of glycinergic synaptic transmission. Located in apical dendrite and neuronal cell body. Orthologous to human SLC7A10 (solute carrier family 7 member 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 101.7), Brain (RPKM 83.5) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (96966030..96982020)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (87829084..87845073)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (91432952..91448566)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Asc-1 activation significantly increased NMDA-R-dependent long-term potentiation (LTP) in both groups of animals and fully rescued the age-related LTP deficits
Title: Asc-1 transporter activation: an alternative to rescue age-related alterations in functional plasticity at rat hippocampal CA3/CA1 synapses.
D-serine heteroexchange through ASC transporters, in particular high affinity ASC1, is present in vivo and may constitute a key component in the regulation of D-serine extracellular concentration.
Title: In vivo D-serine hetero-exchange through alanine-serine-cysteine (ASC) transporters detected by microelectrode biosensors.
Localization of Asc-1 in brain suggests the significant contribution of Asc-1 to amino acid mobilization in brains, including synaptic clearance of D-serine and neuronal uptake of L-serine essential for survival and dendrite growth of Purkinje neurons.
Title: High affinity D- and L-serine transporter Asc-1: cloning and dendritic localization in the rat cerebral and cerebellar cortices.

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General gene information

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Markers

D7Bwg0847e (e-PCR), detects polymorphism
- UniSTS:142663

RH132091 (e-PCR)
- UniSTS:215374

RH131383 (e-PCR)
- UniSTS:214666

Slc7a10 (e-PCR), detects polymorphism
- UniSTS:546023

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables neutral L-amino acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables neutral L-amino acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables neutral L-amino acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables neutral L-amino acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in D-alanine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in D-alanine transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within D-alanine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in D-serine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in D-serine transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within D-serine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in D-serine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in L-alpha-amino acid transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in glycine transport	IEA Inferred from Electronic Annotation more info
involved_in glycine transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of brown fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neutral amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in neutral amino acid transport	ISO Inferred from Sequence Orthology more info
involved_in neutral amino acid transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synaptic transmission, glycinergic	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synaptic transmission, glycinergic	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: asc-type amino acid transporter 1

Names: D- and L-serine transporter Asc-1; D-serine transporter; solute carrier family 7 (cationic amino acid transporter, y+ system), member 10; solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10; solute carrier family 7, (neutral amino acid transporter, y+ system) member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053726.2 → NP_446178.2 asc-type amino acid transporter 1

See identical proteins and their annotated locations for NP_446178.2

Status: PROVISIONAL

Source sequence(s)

AB126813

UniProtKB/TrEMBL

A1L115, A6JAA4, A6JAA5, Q75T81

Related

ENSRNOP00000015205.3, ENSRNOT00000015205.6

Conserved Domains (1) summary

TIGR00911
Location:38 → 503

2A0308; L-type amino acid transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

96966030..96982020

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107883.2 → XP_038963811.1 asc-type amino acid transporter 1 isoform X1

UniProtKB/TrEMBL

A6JAA4

Related

ENSRNOP00000107645.1, ENSRNOT00000132681.1

Conserved Domains (1) summary

TIGR00911
Location:38 → 453

2A0308; L-type amino acid transporter
XM_039107930.2 → XP_038963858.1 asc-type amino acid transporter 1 isoform X2

Conserved Domains (1) summary

TIGR00911
Location:38 → 376

2A0308; L-type amino acid transporter