U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Gp5 glycoprotein V (platelet) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25259, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Symbol
    Gp5provided by RGD
    Full Name
    glycoprotein V (platelet)provided by RGD
    Primary source
    RGD:2724
    See related
    EnsemblRapid:ENSRNOG00000038540 AllianceGenome:RGD:2724
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PLGPV
    Summary
    Predicted to enable collagen binding activity. Predicted to be involved in several processes, including blood coagulation, intrinsic pathway; megakaryocyte development; and positive regulation of platelet activation. Predicted to act upstream of or within cell-matrix adhesion and negative regulation of platelet activation. Located in cell surface. Orthologous to human GP5 (glycoprotein V platelet). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 41.8), Brain (RPKM 10.1) and 3 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Gp5 in Genome Data Viewer
    Location:
    11q22
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (83948507..83952362)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (70443613..70446705)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (73015380..73017570)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095683 Neighboring gene ribosomal protein S26, pseudogene 13 Neighboring gene ATPase 13A3 Neighboring gene leucine rich repeat containing 15 Neighboring gene carboxypeptidase N subunit 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Platelet glycoprotein V binds to collagen and participates in platelet adhesion and aggregation. Moog S, et al. Blood, 2001 Aug 15. PMID 11493449
    2. Increased thrombogenesis and embolus formation in mice lacking glycoprotein V. Ni H, et al. Blood, 2001 Jul 15. PMID 11435305
    3. Increased thrombin responsiveness in platelets from mice lacking glycoprotein V. Ramakrishnan V, et al. Proc Natl Acad Sci U S A, 1999 Nov 9. PMID 10557321, Free PMC Article
    4. Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage. Ravanat C, et al. Blood, 1997 May 1. PMID 9129030
    5. The vascular biology of the glycoprotein Ib-IX-V complex. Berndt MC, et al. Thromb Haemost, 2001 Jul. PMID 11487006

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in blood coagulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in blood coagulation, intrinsic pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in blood coagulation, intrinsic pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in megakaryocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of platelet activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of platelet activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of platelet activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of platelet activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in release of sequestered calcium ion into cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of glycoprotein Ib-IX-V complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of glycoprotein Ib-IX-V complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    platelet glycoprotein V
    Names
    GPV
    Platelet glycoprotein 5
    Platelete glycoprotein 5
    glycoprotein 5, platelet

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012795.3 → NP_036927.2  platelet glycoprotein V precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      O08770
      UniProtKB/TrEMBL
      A6JRV1, G3V9H9
      Related
      ENSRNOP00000047810.2, ENSRNOT00000040884.4
      Conserved Domains (4) summary
      PRK15370
      Location:103 → 422
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      TIGR00864
      Location:394 → 458
      PCC; polycystin cation channel protein
      sd00033
      Location:100 → 123
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:64 → 110
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      83948507..83952362
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270306.1 → XP_063126376.1  platelet glycoprotein V isoform X1

      UniProtKB/Swiss-Prot
      O08770
      UniProtKB/TrEMBL
      A6JRV1, G3V9H9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08770.1 GenPept UniProtKB/Swiss-Prot:O08770

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous