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    Ube2v2 ubiquitin conjugating enzyme E2 V2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287927, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ube2v2provided by RGD
    Official Full Name
    ubiquitin conjugating enzyme E2 V2provided by RGD
    Primary source
    RGD:727838
    See related
    EnsemblRapid:ENSRNOG00000001829 AllianceGenome:RGD:727838
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MMS2
    Summary
    Involved in negative regulation of neuron apoptotic process; positive regulation of cellular component organization; and positive regulation of macromolecule metabolic process. Predicted to be located in nucleoplasm. Predicted to be part of UBC13-MMS2 complex. Predicted to be active in nucleus. Orthologous to human UBE2V2 (ubiquitin conjugating enzyme E2 V2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 189.4), Muscle (RPKM 155.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ube2v2 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (98808681..98842583)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (85304528..85338430)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (89557273..89591175)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene translation machinery-associated protein 16 pseudogene Neighboring gene protein kinase, DNA-activated, catalytic subunit Neighboring gene minichromosome maintenance complex component 4 Neighboring gene U2 spliceosomal RNA Neighboring gene RNA polymerase II subunit M, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of numerous genes differentially expressed in rat brain during postnatal development by suppression subtractive hybridization and expression analysis of the novel rat gene rMMS2. Hofsaess U, et al. Brain Res Mol Brain Res, 2003 May 12. PMID 12750002
    2. Recurrent carcinoma of the rectum, surgical treatment. JACKSON BR, et al. Calif Med, 1959 Sep. PMID 14406273, Free PMC Article
    3. Molecular cloning and functional characterization of two murine cDNAs which encode Ubc variants involved in DNA repair and mutagenesis. Franko J, et al. Biochim Biophys Acta, 2001 May 28. PMID 11406273
    4. A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination. Zhao GY, et al. Mol Cell, 2007 Mar 9. PMID 17349954
    5. Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A. Andersen PL, et al. J Cell Biol, 2005 Aug 29. PMID 16129784, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105268

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in DNA double-strand break processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA double-strand break processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within error-free postreplication DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of double-strand break repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein K63-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in postreplication repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K63-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of UBC13-MMS2 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of UBC13-MMS2 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin conjugating enzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-conjugating enzyme E2 variant 2
    Names
    ubiquitin-conjugating enzyme E2v2
    ubiquitin-conjugating enzyme variant MMS2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183052.2 → NP_898875.1  ubiquitin-conjugating enzyme E2 variant 2

      See identical proteins and their annotated locations for NP_898875.1

      Status: VALIDATED

      Source sequence(s)
      FM082155, JAXUCZ010000011
      UniProtKB/Swiss-Prot
      Q7M767, Q8CHN0
      UniProtKB/TrEMBL
      A0A8I6AKD9, A6JSS2
      Conserved Domains (1) summary
      smart00212
      Location:14 → 145
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      98808681..98842583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597891.3 → XP_017453380.1  ubiquitin-conjugating enzyme E2 variant 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZN23, A0A8I6AJF4
      Conserved Domains (1) summary
      smart00212
      Location:29 → 160
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    2. XM_039088057.2 → XP_038943985.1  ubiquitin-conjugating enzyme E2 variant 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AKD9, A6JSS3
      Related
      ENSRNOP00000079261.2, ENSRNOT00000111871.2
      Conserved Domains (1) summary
      smart00212
      Location:18 → 149
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7M767.3 GenPept UniProtKB/Swiss-Prot:Q7M767

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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