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    Rbm8a RNA binding motif protein 8A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295284, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rbm8aprovided by RGD
    Official Full Name
    RNA binding motif protein 8Aprovided by RGD
    Primary source
    RGD:1310099
    See related
    EnsemblRapid:ENSRNOG00000021215 AllianceGenome:RGD:1310099
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rbm8
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and regulation of gene expression. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in thrombocytopenia-absent radius syndrome. Orthologous to human RBM8A (RNA binding motif protein 8A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 39.8), Spleen (RPKM 39.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rbm8a in Genome Data Viewer
    Location:
    2q34
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (186854018..186856802)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (184165189..184167959)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (198755261..198758028)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 34A Neighboring gene limb and CNS expressed 1 like Neighboring gene high mobility group protein B1-like Neighboring gene peroxisomal biogenesis factor 11 beta Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC134485661

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA binding  
    enables mRNA binding  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    part_of U2-type catalytic step 1 spliceosome  
    part_of U2-type catalytic step 1 spliceosome  
    part_of catalytic step 2 spliceosome  
    located_in cytoplasm  
    located_in dendrite PubMed 
    part_of exon-exon junction complex  
    part_of exon-exon junction complex  
    part_of exon-exon junction subcomplex mago-y14  
    located_in neuronal cell body PubMed 
    located_in nuclear speck  
    located_in nuclear speck  
    located_in nucleus  

    General protein information

    Preferred Names
    RNA-binding protein 8A
    Names
    RNA binding motif protein 8
    ribonucleoprotein RBM8A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271138.1NP_001258067.1  RNA-binding protein 8A

      See identical proteins and their annotated locations for NP_001258067.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q27W01
      UniProtKB/TrEMBL
      A6K380
      Related
      ENSRNOP00000028807.4, ENSRNOT00000028807.9
      Conserved Domains (1) summary
      cd12324
      Location:67151
      RRM_RBM8; RNA recognition motif (RRM) found in RNA-binding protein RBM8A, RBM8B nd similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      186854018..186856802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232956.5XP_006233018.1  RNA-binding protein 8A isoform X1

      See identical proteins and their annotated locations for XP_006233018.1

      Conserved Domains (1) summary
      cd12324
      Location:66150
      RRM_RBM8; RNA recognition motif (RRM) found in RNA-binding protein RBM8A, RBM8B nd similar proteins
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