Sepsecs Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sepsecsprovided by RGD
Official Full Name: Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthaseprovided by RGD
Primary source: RGD:1589491
See related: EnsemblRapid:ENSRNOG00000049244 AllianceGenome:RGD:1589491
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable tRNA binding activity. Predicted to be involved in selenocysteine incorporation. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2D. Orthologous to human SEPSECS (Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 261.3), Kidney (RPKM 147.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (62524287..62554529)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (58311484..58341745)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (60657730..60687950)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH131015 (e-PCR)
- UniSTS:214298

BM386109 (e-PCR)
- UniSTS:261146

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables O-phosphoseryl-tRNA(Sec) selenium transferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in conversion of seryl-tRNAsec to selenocys-tRNAsec	IEA Inferred from Electronic Annotation more info
involved_in selenocysteine incorporation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: O-phosphoseryl-tRNA(Sec) selenium transferase

NP_001121759.1

EC 2.9.1.2

XP_038948337.1

EC 2.9.1.2

XP_038948339.1

EC 2.9.1.2

XP_038948340.1

EC 2.9.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001128287.2 → NP_001121759.1 O-phosphoseryl-tRNA(Sec) selenium transferase

See identical proteins and their annotated locations for NP_001121759.1

Status: PROVISIONAL

Source sequence(s)

BC166584

UniProtKB/TrEMBL

A6IJH3, B2GV97, M0R860

Related

ENSRNOP00000065651.1, ENSRNOT00000070892.4

Conserved Domains (1) summary

TIGR03531
Location:13 → 458

selenium_SpcS; O-phosphoseryl-tRNA(Sec) selenium transferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

62524287..62554529

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092409.2 → XP_038948337.1 O-phosphoseryl-tRNA(Sec) selenium transferase isoform X1

Conserved Domains (1) summary

TIGR03531
Location:13 → 403

selenium_SpcS; O-phosphoseryl-tRNA(Sec) selenium transferase
XM_039092411.2 → XP_038948339.1 O-phosphoseryl-tRNA(Sec) selenium transferase isoform X2

Conserved Domains (1) summary

TIGR03531
Location:13 → 372

selenium_SpcS; O-phosphoseryl-tRNA(Sec) selenium transferase
XM_039092412.2 → XP_038948340.1 O-phosphoseryl-tRNA(Sec) selenium transferase isoform X3

Conserved Domains (1) summary

cl18945
Location:1 → 317

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...